Moutasim, Karwan - University of Southampton

个人简介

Karwan Moutasim was appointed as an NIHR Clinical Lecturer in Pathology in 2012. He obtained his Dental degree from the University of Jordan in 2002. After completing a period of general professional training, he gained MFD RCS in 2006. In 2007, he completed an MSc in Experimental Oral Medicine with Distinction from King’s College London, following which he gained the Membership in Oral Medicine (MOMed RCSEd). He was awarded the Royal Society of Medicine President’s Prize (Odontology Section) in 2009. Later that year, he was awarded a Cancer Research UK Clinical Research Training Fellowship to carry out his PhD within Prof. Gareth Thomas’ Experimental Pathology laboratory at the Cancer Sciences Unit, University of Southampton. In 2011, he was awarded the Southampton Clinical Academic Trainees’ Prize for Best Research Paper. The following year, he was awarded the Oral Plenary Research Presentation Prize by the Pathological Society of Great Britain and Ireland.

研究领域

Our research focuses on cancer cell biology with a strong emphasis on the tumour microenvironment. This work is carried out within The Experimental Pathology Group (headed by Professor Gareth Thomas), which comprises a multi-disciplinary research team consisting of post-doctoral research fellows, PhD students, clinical research fellows and clinical research nurses. Current funded studies (principal investigator or co-investigator): Epithelial to mesenchymal transition (EMT) in head and neck cancer Interactions of Hedgehog signalling pathway with integrins in cancer Transcriptional regulation of integrins in carcinogenesis Prognostic and predictive factors in head and neck cancer

近期论文

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Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis - Mellone, Massimiliano, Hanley, Christopher, Thirdborough, Stephen, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steven, Jenei, Veronika, Moutasim, Karwan, Kabir, Tasnuva D., Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W., Prime, Stephen S., Underwood, Timothy J., Vijayanand, Pandurangan, Eliceiri, Kevin W., Woelk, Christopher, King, Emma, Gil, Jesus, Ottensmeier, Christian and Thomas, Gareth Published:2016Publication:AgingPage Range:1-19doi:10.18632/aging.101127PMID:27992856 Suppression of hedgehog signalling promotes pro-tumourigenic integrin expression and function - Moutasim, Karwan A., Mellows, Toby, Mellone, Massimiliano, Lopez, Marie-Antoinette, Tod, Joanne, Kiely, Philip C., Sapienza, Karen, Greco, Azzura, Neill, Graham, Violette, Shelia, Weinreb, Paul, Marshall, John, Ottensmeier, Christian H., Sayan, A.E., Jenei, V. and Thomas, Gareth J. Published:2014Publication:The Journal of PathologyVolume:233, (2)Page Range:196-208doi:10.1002/path.4342PMID:24573955 In vitro effect of bisphosphonates on oral keratinocytes and fibroblasts - McLeod, Niall , Moutasim, Karwan A., Brennan, Peter, Thomas, Gareth J and Jenei, Veronika Published:2013Publication:Journal of Oral and Maxillofacial Surgerydoi:10.1016/j.joms.2013.08.007 GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state - Nadendla, Sandeep K., Hazan, Allon, Ward, Matt, Harper, Lisa J., Moutasim, Karwan, Bianchi, Lucia S., Naase, Mahmoud, Ghali, Lucy, Thomas, Gareth J., Prowse, David M., Philpott, Michael P. and Neill, Graham W. Published:2011Publication:PLoS ONEVolume:6, (5)Page Range:e20271-[13pp]doi:10.1371/journal.pone.0020271PMID:21633508