Morrison, Karen E - University of Southampton

个人简介

Karen graduated in Medicine from the University of Cambridge (1983, BA, 1986 MA) and University of Oxford (1986, BMBCh). Following postdoctoral research in the Department of Internal Medicine at Yale University USA, she returned to Oxford supported by MRC and Wellcome Trust Fellowships, undertaking research into inherited disorders of motor nerves. She was appointed Medical Research Fellow at Corpus Christi College, Oxford and completed her clinical training in neurology at the Radcliffe Infirmary, where she was appointed Honorary Consultant Neurologist in 1998. In 1999 she took up the post of Bloomer Professor of Neurology at the University of Birmingham, combining research into molecular genetic mechanisms in neurodegenerative disease with neurology/neuroscience teaching and overview and strategic development of the undergraduate MBChB final year. As a clinical neurologist she co-directed the Birmingham Motor Neurone Disease Care and Research Centre at the Queen Elizabeth Hospital, and also led the first national service for adults with Wolfram Syndrome. She has published over 150 peer reviewed articles, mainly on clinical and molecular genetic aspects of neurodegenerative disease. Her laboratory research has investigated molecular mechanisms in Motor Neurone Disease and Parkinson’s disease, underpinned by establishing large DNA banks linked to clinical and epidemiological data. She serves on several national and international panels advising on clinical and research aspects of neurodegeneration. Karen moved to the University of Southampton in 2016, to lead the education programmes within the Faculty of Medicine. Current key roles include ensuring that all Faculty programmes are up-to-date, relevant and responsive so that graduates are equipped with the clinical, academic and professional skills to ensure successful careers in medicine and research as lifelong learners.

研究领域

Molecular and genetic studies in neurodegeneration – particular focus on motor neurone disease MND/amyotrophic lateral sclerosis and Parkinson’s disease. Investigation of both sporadic and familial disease, genome wide association studies, whole genome sequencing studies, investigation of glutamate excitotoxicity. Establishing large DNA banks from people with various neurodegenerative disorders, linked to clinical and epidemiological data, including the UK MND Biobank (funded by the MND Association UK) and Parkinson’s Disease DNA Bank ‘PDGEN’ (funded via MRC and Parkinson’s UK). Samples from these banks are widely used in large collaborative research studies, nationally and internationally. Work to date has included several genome wide association studies including studies of copy number variation and homozygosity mapping. Clinical research in motor neurone disease, with interests in therapeutic clinical trials, standards of care and end-of-life decision making.

近期论文

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Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised placebo-controlled phase 2 trial - Meininger, Vincent, Genge, Angela, van den Berg, Leonard and Morrison, Karen Published:2017Publication:Lancet NeurologyPage Range:1-24 Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study - Wang, Lisa, Heckman, Michael G., Aasly, Jan O., Annesi, Grazia, Bozi, Maria, Chung, Sun Ju, Clarke, Carl, Crosiers, David, Eckstein, Gertrud, Garraux, Gaetan, Hadjigeorgiou, Georgios M., Hattori, Nobu, Jeon, Beom, Kim, Yun J., Kubo, Masato, Lesage, Suzanne, Lin, Juei Jueng, Lynch, Timothy, Lichtner, Peter, Mellick, George D., Mok, Vincent, Morrison, Karin, Quattrone, Aldo, Satake, Wataru, Silburn, Peter A., Stefanis, Leonidas, Stockton, Joanne D., Tan, Eng King, Toda, Tatsushi, Brice, Alexis, Van Broeckhoven, Christine, Uitti, Ryan J., Wirdefeldt, Karin, Wszolek, Zbigniew, Xiromerisiou, Georgia, Maraganore, Demetrius M., Gasser, Thomas, Krüger, Rejko, Farrer, Matthew J., Ross, Owen A. and Sharma, Manu Published:2016Publication:Neurobiology of AgingVolume:49Page Range:217.e1-217.e4doi:10.1016/j.neurobiolaging.2016.09.022 Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis - Gaastra, Benjamin, Shatunov, Aleksey, Pulit, Sara, Jones, Ashley R., Sproviero, William, Gillett, Alexandra, Chen, Zhongbo, Kirby, Janine, Fogh, Isabella, Powell, John F., Leigh, P. Nigel, Morrison, Karen E., Shaw, Pamela J., Shaw, Christopher E., van den Berg, Leonard H., Veldink, Jan H., Lewis, Cathryn M. and Al-Chalabi, Ammar Published:2016Publication:Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationPage Range:1-7doi:10.1080/21678421.2016.1213852 A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis - McGeachan, Alexander J., Hobson, Esther V., Al-Chalabi, Ammar, Stephenson, Jodie, Chandran, Siddharthan, Crawley, Francesca, Dick, David, Donaghy, Colette, Ellis, Cathy M., Gorrie, George, Hanemann, C. Oliver, Harrower, Timothy, Jung, Agam, Malaspina, Andrea, Morrison, Karen E., Orrell, Richard W., Talbot, Kevin, Turner, Martin R., Williams, Timothy L., Young, Carolyn A., Shaw, Pamela J. and McDermott, Christopher J. Published:2016Publication:Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationPage Range:1-9doi:10.1080/21678421.2016.1221433