Millar, Timothy - University of Southampton

个人简介

Qualifications BSc (Hons) Biological Sciences, University of Birmingham (1992) PhD, University of Bath (2000) Postgraduate Certificate in Academic Practice, University of Southampton (2008) Appointments held Sep 2003 - Sep ’06 CIHR Postdoctoral Training Fellowship in Translational Research, Immunology Research Group, University of Calgary, Calgary, Alberta, Canada. Oxygen sensing, MAPkinase signalling and leukocyte recruitment to the endothelium during ischaemia reperfusion Jan 2000, Jun ‘03 Postdoctoral Research Fellow Bone and Joint Research Group, Department of Medical Sciences, University of Bath, Bath. Nitric oxide and peroxynitrite generation from xanthine oxidase, its various roles as an antibiotic and inflammatory mediator. Aug 95 – Dec 99 PhD student, Bone and Joint Research Unit, University of London, London / Bone and Joint Research Group, University of Bath, Bath. Novel aspects of the activity and function of xanthine oxidase Jan 94 - Jun 95 Research Assistant, Coagulation Research, St Thomas’ Hospital, London. Fibrinogen binding to human melanoma cells and its effect on metastatic potential Jan 93 – Dec 93 Research Assistant, Biochemical Sciences, Wellcome Foundation Ltd, Beckenham, Kent. Neutrophil priming and secretion: signalling through phospholipase D

研究领域

Inflammation and regulatory T cell activation Inflammation is a natural response to environmental stimuli but chronic inflammation can lead to compromised function. The body has a mechanism of controlling inflammation using regulatory T cells which help to return an inflammatory area back to normal physiology. In chronic inflammatory skin disease the role of the regulatory T cell and the interaction with the dermal endothelium is being studied as the mechanism of T cell activation via Programmed Death Receptor 1 (PD-1R) and its ligand requires an initial interaction with the vascular wall. This study will lead to potential new therapeutics to control T reg activity in the skin and other organs. Funding: British Skin Foundation Collaborators: Dr Chris Pickard, Prof Eugene Healy Cancer cell recruitment, MAPKinase and endothelial activation Inflammatory cells must interact with the vascular wall before transmigrating into the surrounding tissue. Cancer cells which have broken away from the primary tumour use similar mechanism during spread through the blood system so called haematogenous spread. We are detailing the interaction of breast cancer cells and the endothelium under flow conditions to mimic physiology and also in the presence of platelets as part of the recruitment process involves activation of the coagulation cascades. This study is using small molecule inhibitors to block endothelial activation and the interaction of platelets and cancer cells. Nano particles and angiogenesis New blood vessel formation (angiogenesis) is a required and carefully orchestrated event under normal physiological conditions. However, new blood vessel growth into tumours increases the risk of cancer spread. We are using novel nanotechnology to control angiogenesis in an attempt to reduce the spread of primary tumours. In collaboration with the Faculty of Astronomy and Physics, we are using gold nanoparticles to target endothelial cells directly, to block their ability to attach to basement matrix proteins and therefore prevent angiogenesis. We are also using tuned laser technology to target endothelial cells which contain gold nanoparticles in an attempt to ablate new blood vessel formation. Funding: EPSRC Collaborators: Dr Antonios Kanaras, Dr Tilman Sanchez-Eisner, Dr Otto Muskens, Dr Dorota Bartzak Microfluidic devices and 3D models of extrasvasation Modelling vascular parameters and devising microfluidic devices for use in biological research is an important method which will increase the complexity of invitro assays and reduce the requirement for animals in biological research. To this end we are developing microfluidic devices which mimic the vasculature and allow models of the lung or vascular beds to be formed. These devices use isolated human cells and sensors to measure important biological parameter such as permeability, oxygen and glucose. We are also developing in gel 3D vascular networks which will allow modelling of flow dynamics and provide an invitro assay of cancer intra and extravasation. Funding: NC3Rs, FP7 (pending), AAIR Collaborators: Dr Xunli Zhang, Dr Dyan Ankrett, MITHRA, Prof. Donna Davies, Prof Hywel Morgan

近期论文

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Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA - Blume, Cornelia, Reale, Riccardo, Held, Marie, Loxham, Matthew, Millar, Tim, Collins, Jane, Swindle, Emily, Morgan, Hywel and Davies, Donna Published:2016Publication:Immunity, Inflammation and DiseasePage Range:1-34 Temporal monitoring of differentiated human airway epithelial cells using microfluidics - Blume, Cornelia, Reale, Riccardo, Held, Marie, Millar, Timothy M., Collins, Jane E., Davies, Donna E., Morgan, Hywel and Swindle, Emily J. Published:2015Publication:PLoS ONEVolume:10, (10)Page Range:1-13doi:10.1371/journal.pone.0139872PMID:26436734 Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation - Bartczak, Dorota, Muskens, Otto L., Nitti, Simone, Millar, Timothy M. and Kanaras, Antonios G. Published:2015Publication:Biomaterials ScienceVolume:3, (5)Page Range:733-741doi:10.1039/C5BM00053J Nanoparticulate drugs for the manipulation of angiogenesis - Millar, Timothy M. and Kanaras, Antonios G. Published:2013Publication:Therapeutic DeliveryVolume:4, (10)Page Range:1217-1219doi:10.4155/tde.13.96 Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles - Bartczak, Dorota, Muskens, Otto L., Sanchez-Elsner, Tilman, Kanaras, Antonios G. and Millar, Timothy M. Published:2013Publication:ACS NanoVolume:7, (6)Page Range:5628-5636doi:10.1021/nn402111z