McGrath, Nuala - University of Southampton

个人简介

Professor Nuala McGrath is Professor of Epidemiology and Sexual Health; Wellcome Trust Career Development Fellow within Medicine at the University of Southampton. Nuala has worked in HIV research since 1989. First as a biostatistician supporting clinical trials in the USA, and later in clinical trials and epidemiological research in Africa. After completing her PhD in Infectious Disease Epidemiology at Harvard School of Public Health in 2002, she was Principal Investigator of a microbicide study at the Africa Centre for Health and Population Studies in KwaZulu-Natal, South Africa (2002-2004), and the Field Director for the London School of Hygiene and Tropical Medicine’s Karonga Prevention Study research programme in Malawi (2005-2006) and based in South Africa again from 2006-2013. Her research explores HIV transmission dynamics, sexual behaviour and relationship dynamics in the era of HIV treatment and testing couples-based interventions to reduce HIV transmission. Nuala joined the University of Southampton as a Reader in Infectious Disease Epidemiology in 2013 and was promoted to Professor of Epidemiology and Sexual Health on 1 August 2015. Nuala has been a Wellcome Trust Research Career Development Fellow since 2008 and holds Honorary appointments with the College of Health Sciences, University of KwaZulu-Natal (Honorary Professor) and in Infection and Population Health / Centre for Sexual Health & HIV Research, University of College London (Honorary Reader). Nuala is also part of the Senior Faculty of the Africa Centre for Health and Population Studies in KwaZulu-Natal, South Africa.

研究领域

Nuala’s current research and scholarship is characterised by four main activities: Sexual behaviour and relationship dynamics Nuala’s primary research addresses sexual behaviour and sexual health; in recent years this has chiefly meant exploring sexual behaviour and relationship dynamics in the era of antiretroviral treatment (ART) rollout in South Africa. Her research examines how sexual behaviour has changed with the availability of ART, how it continues to facilitate the onward transmission of HIV, and how sexual health practices contribute to HIV infection. Her research (prospective studies and secondary analyses) has shown that general population sexual risk behaviours have not increased as a result of treatment rollout; neither have they increased among people living with HIV. Nuala’s work has informed debates on the role of hormonal contraception use on HIV acquisition, intravaginal practices and the particularly contentious debate on whether concurrency is a key driver of the HIV epidemic. She has also contributed as an expert to the UNAIDS Reference Group On Estimates Modelling And Projections guidelines on measuring concurrent sexual partnerships. Extending her sexual behaviour and STI work to the UK, she is working with the Sexual Health Services team at Solent NHS Trust, through the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) Wessex, to evaluate strategies to improve effectiveness and efficiency of the sexual health service and develop interventions targeting high STI risk sexual behaviours associated with substance misuse. HIV testing, HIV prevention and treatment Evaluating HIV treatment and prevention strategies including the promotion of HIV testing to reduce the onward transmission of HIV is another critically important and long standing theme in Nuala’s work. Many of these studies have involved the kind of multi-centre and multi-country research networks that are necessary to conduct research on the scale required to definitively answer key questions on HIV prevention. Currently, she has a senior scientific role on the study steering committee of three important HIV prevention trials: a French national research agency on HIV and viral hepatitis (ANRS) funded Treatment as Prevention (TasP) Trial, a large (N=22,000) community cluster-randomised trial; a US National Institute of Mental Health funded Project Accept (HPTN 043), a large cluster-randomised trial among 48 communities in Africa and Thailand; and the first couples-based intervention randomised controlled trial to have couples HIV counselling and testing (CHCT) as its outcome (Uthando Lwethu), funded by the US National Institute of Health. Chronic Diseases Antiretroviral treatment has resulted in HIV becoming a chronic disease, dramatically increased life expectancy and facilitated new epidemics of non-communicable and infectious chronic disease co-morbidities in Sub-Saharan Africa. Nuala is the Southampton lead on a programme of work on multi-morbidity with collaborators at the University of Cape Town, South Africa, Pennsylvania State University, USA, and Soton colleagues. Linked to this theme of non-communicable diseases, she is collaborating with Soton colleagues to explore the feasibility of delivering health-related interventions via smartphones in a rural African context.

近期论文

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Health behaviour change interventions for couples: a systematic review - Mcgrath, Nuala and Arden-Close, Emily Published:2016Publication:British Journal of Health PsychologyPage Range:1-23 Pneumococcal conjugate vaccine implementation in middle-income countries - Tricarico, Serena, McNeil, Hannah C., Cleary, David W., Head, Michael G., Lim , Victor, Kok Seng Yap, Ivan, Chun Wie, Chong, Siang Tan, Cheng, Norazmi, Mohd Nor, Ismail, Aziah, Seong Guan Cheah, Eddy, Faust, Saul N., Jefferies, Johanna M.C., Roderick, Paul J., Moore, Michael, Yuen, Ho Ming, Newell, Marie-Louise, Mcgrath, Nuala, Webb, Jeremy, Doncaster, C. Patrick, Kraaijeveld, Alex R., Webb, Jeremy S. and Clarke, Stuart C. Published:2016Publication:PneumoniaPage Range:1-26 Factors associated with pre-ART loss-to-follow up in adults in rural KwaZula-Natal, South Africa: a prospective cohort study - Evangeli, Michael, Newell, Marie-Louise and Mcgrath, Nuala Published:2016Publication:BMC Public HealthVolume:16, (358)Page Range:1-13doi:10.1186/s12889-016-3025-xPMID:27117271 Editorial. Advancing STI care in low and middle income countries: has STI syndromic management reached its use-by date? - Garrett, Nigel, Mcgrath, Nuala, Mindel, Adrian and , Published:2016Publication:Sexually Transmitted InfectionsPage Range:1-6doi:10.1136/sextrans-2016-052581PMID:27084840