McCormick, Christopher - University of Southampton

个人简介

Dr Christopher McCormick is Lecturer within Medicine at the University of Southampton.Dr McCormick joined the University of Southampton in May 2005, where he has continued his work investigating mechanisms of positive strand RNA virus replication. Originally trained as a parasitologist in the University of Oxford, he move to the University of Leeds in 1996, taking up a three year post-doctoral position to study malaria sporozoite invasion of the liver, before becoming interested in another hepatotropic infectious agent, hepatitis C virus. Six years later, after involvement in a number of studies that included being the first to show that a DNA-based delivery system could be used to introduce replication-competent viral transcripts into cells, he brought his experience to Southampton. Working with Prof Ian Clarke and other colleagues he showed that the same DNA-based delivery system could be used to recover infectious mouse norovirus; a discovery that for the first time allowed researchers to delve into the genetics of norovirus, a group of viruses that include Norwalk or ‘Winter Vomiting” Virus. More recently, he has developed a novel hepatitis C virus genetics system as a proof-of-principle that traditional hurdles to undertaking genetic complementation studies in positive strand RNA viruses can be overcome. Dr McCormick is a member of the Society for General Microbiology and American Society for Microbiology. He is an editorial board member for Journal of General Virology and for 4 years co-ordinated the Recent Independent Virology Researcher’s UK Meeting.

研究领域

Chris is interested in the molecular mechanisms that underpin positive strand RNA virus replication and the how these groups of viruses are able to avoid immunity and cause disease.

近期论文

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Polyprotein driven formation of two independent sets of complexes supporting hepatitis C virus genome replication - Gomes, Rafael, Isken, Olaf, Tautz, Norbert, McLauchlan, John and McCormick, Christoper J. Published:2015Publication:Journal of VirologyPage Range:1-53doi:10.1128/JVI.01931-15PMID:26719260 Interaction between the NS4B amphipathic helix, AH2, and charged lipid headgroups alters membrane morphology and AH2 oligomeric state — Implications for the Hepatitis C virus life cycle - Ashworth Briggs, Esther L., Gomes, Rafael G.B., Elhussein, Malaz, Collier, William, Stuart Findlow, I., Khalid, Syma, McCormick, Chris J. and Williamson, Philip T.F. Published:2015Publication:Biochimica et Biophysica Acta (BBA) - BiomembranesVolume:1848, (8)Page Range:1671-1677doi:10.1016/j.bbamem.2015.04.015 The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated - Paul, David, Bartenschlager, Ralf and McCormick, Christopher J. Published:2015Publication:Journal of General VirologyPage Range:1-15doi:10.1099/vir.0.000111PMID:25740959 NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system - Bentham, M. J., Marraikii, N., McCormick, C.J., Rowlands, D. J. and Griffin, S. Published:2014Publication:Journal of General Virologydoi:10.1099/vir.0.068932-0PMID:25024280 Genetic Complementation of Hepatitis C Virus Nonstructural Protein Functions Associated with Replication Exhibits Requirements That Differ from Those for Virion Assembly - Herod, Morgan R., Shregel, Vera, Hinds, Christopher, Liu, Mengya, McLauchlan, John and McCormick, Christopher J. Published:2013Publication:Journal of VirologyVolume:88Page Range:2748-2762doi:10.1128/JVI.03588-13PMID:24352463