Mansour, Salah - University of Southampton

个人简介

Dr Salah Mansour is Research Fellow within Medicine at the University of Southampton. He leads a research group that employs a multidisciplinary approach to study the biological functions of CD1 molecules and their presentation of lipid antigens to T cells. This has broad relevance to human diseases, including tuberculosis, cancer, and autoimmune conditions. His interest into antigen presentation started with a PhD in Immunology at Professor Ping Wang’s lab at Barts Medical School, Queen Mary University of London, based on studies that focussed on the MHC class I antigen presentation pathway. After a short stint in industry, Dr Mansour joined Professor Stephan Gadola’s CD1 research group in Clinical and Experimental Sciences, Faculty of Medicine, Southampton in 2008. He has led translational and basic immunology studies on CD1 antigen presentation that aim at understanding the role of iNKT cells in the early stages of human autoimmune diseases and the molecular basis of Group 1 CD1 antigen presentation to human T cells in cancer and infection. Dr Mansour’s current research program integrates chemistry and biology approaches with clinical medicine to develop new therapeutics and diagnostics to improve human health. He has developed strong collaborations with computational and synthetic chemists, structural biologists, and with tuberculosis and cancer clinicians. He also has strong links with Public Health England Porton Down (Dr Sally Sharpe).

研究领域

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The role of the CD1 antigen presentation pathway is to present lipid antigens to specific T cells of the human immune system, and evidence indicates that these T cell responses can either have protective roles in infectious diseases such as Mycobacterium Tuberculosis infection or regulatory roles in autoimmune diseases such as Rheumatoid Arthritis. Central to the research goals of the CD1 group at Southampton is to understand CD1 antigen presentation by developing molecular diagnostic tools to study CD1 dependent T cell responses in human health and disease.