Macklon, Nicholas Stephen - University of Southampton

个人简介

Nick Macklon trained in Edinburgh, and carried out his doctoral research in Glasgow before taking a Fellowship in Fetal Medicine in Rotterdam where he was subsequently appointed Senior Lecturer and Director of the Assisted Conception Unit. In 2005 he was appointed Professor of Periconceptional Medicine and Infertility at the Utrecht University Medical Centre, where he became Head of the Department of Reproductive Medicine and Gynaecology. In 2009 he was appointed to the Chair in Obstetrics and Gynaecology in Southampton, where he is also Director of the Complete Fertility Centre Southampton. Professor Macklon has published more than 100 Pubmed cited articles in the fields of ovarian stimulation and endometrial receptivity. In addition to contributing chapters to standard texts in the field, he has published two books, the award winning IVF in the Medically Complicated Patient, and more recently the Textbook of Periconceptional Medicine. External appointments include Past Chairman of the ESHRE Special Interest Group on Reproductive Endocrinology, Founding Board Member of the Dutch Society of Reproductive Medicine. He is currently editorial board member of Reproduction, Fertility and Sterility and Reproductive Biomedicine Online. He holds Visiting Professorships in Adelaide University, Australia, and Utrecht University, The Netherlands.

研究领域

The embryo selection window and recurrent miscarriage Working with Jan Brosens, we have developed a novel paradigm for the role of human decidualised endometrium to sense embryo quality and prevent implantation of poorly viable embryos. We are now investigating how this selection mechansism may be disrupted in women with recurrent miscarriage. The fate of the early human embryo Our group coined the now widely used term describing the ‘Black Box of early Pregnancy Loss’ Over the past few years we have carried out a number of studies aimed understanding the fate of the preimplantation and post implantation human embryo. These studies involve in-vitro culture system to study chromosome repair mechanisms, and longitudinal studies of determinants of implantation failure. We are also exploring new markers for in-vivo conception in the human. The study of the impact of nutritional status on the human reproductive tract Having pioneered the analysis of endometrial secretions to determine the receptivity of the uterus to implantation, we are now working with Judith Eckert and Franchesca Houghton to develop this technique to allow interrogation of the nutritional environment of the preimplantation human embryo. This work will enable us to identify modulatable factors to optimise this environment and lead to new interventions aimed at increasing succeful implantation and crucial early growth.

近期论文

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Medical and social egg freezing: internet based survey of knowledge and attitudes among women in Denmark and the UK - Lallemant, C., Vassard, D., Nyboe Andersen, A., Schmidt, L. and Macklon, N. Published:2016Publication:Acta Obstetricia Et Gynecologica ScandinavicaPage Range:1-9doi:10.1111/aogs.13024PMID:27638056 Reply: the impact of an inappropriate non-inferiority margin in a non-inferiority trial. - Groenewoud, E., Kollen, B., Macklon, N. and Cohlen, B Published:2016Publication:Human ReproductionVolume:31, (12)Page Range:2893doi:10.1093/humrep/dew258 PMID:27742725 Is timing of the first antenatal visit associated with adverse birth outcomes? Analysis from a population-based birth cohort - Alwan, Nisreen A., Roderick, Paul J. and Macklon, Nick S. Published:2016Publication:The Lancet A population-based survey on family intentions and fertility awareness in women and men in the United Kingdom and Denmark - Vassard, Ditte, Lallemant, Camille, Andersen, Anders Nyboe, Macklon, Nicholas and Schmidt, Lone Published:2016Publication:Upsala Journal of Medical SciencesPage Range:1-9doi:10.1080/03009734.2016.1194503PMID:27347691 A randomized controlled, non-inferiority trial of modified natural versus artificial cycle for cryo-thawed embryo transfer - Groenewoud, E.R., Cohlen, B.J., Al-Oraiby, A., Brinkhuis, E.A., Broekmans, F.J.M., de Bruin, J.P., van den Dool, G., Fleisher, K., Friederich, J., Goddijn, M., Hoek, A., Hoozemans, D.A., Kaaijk, E.M., Koks, C.A.M., Laven, J.S.E., van der Linden, P.J.Q., Manger, A.P., Slappendel, E., Spinder, T., Kollen, B.J. and Macklon, N.S. Published:2016Publication:Human ReproductionPage Range:1-10doi:10.1093/humrep/dew120PMID:27179265