Lucas, Jane - University of Southampton

个人简介

Jane Lucas is a Professor of Paediatric Respiratory Medicine at University of Southampton. Jane leads the national primary ciliary dyskinesia (PCD) centre in Southampton. Her respiratory research is focused on understanding the pathophysiology of PCD and improving management of patients with this disease. She also investigates the role of ciliated respiratory epithelium in disease and health, including the interaction between cilia and bacteria. Her allergy research includes the early life origins of asthma and allergy, identifying predictive markers of allergy severity, and the psychosocial aspects of food allergies. Jane’s programme closely integrates clinical service, research and education, and team compromises clinicians, laboratory scientists and social scientists.

研究领域

Professor Lucas’s research focuses on improving the diagnosis and management of children with allergic and respiratory disease. She also leads research to understand the underlying causes of these diseases in the anticipation that we will one day be able to prevent allergy and chest diseases in children. Primary Ciliary Dyskinesia Primary Ciliary Dyskinesia (PCD) is a relatively rare disease that causes chronic lung disease, rhinosinusitis, glue ear and infertility. Dr Lucas directs a national centre to diagnose PCD in adults and children, and runs a specialist clinic for children with the disease. Dr Lucas is leading research to ensure that children with PCD stay healthy throughout childhood. Early diagnosis is important to prevent irreversible lung damage, but current investigations are difficult to perform and often lead to inconclusive results. She is therefore investigating novel methods to improve diagnosis. She is work package leader for a European FP7 funded study, BESTCILIA, aimed at improving the diagnosis and management of PCD. She chairs the European Respiratory Society Task Force (TF-2014-04) which is developing evidence based guidelines for the diagnosis of PCD. Once diagnosed, there is no cure for PCD, and recurrent infections associated with irreversible deterioration in lung function can occur despite adherence to treatment guidelines. Dr Lucas’ team are investigating how the ciliated respiratory epithelium interacts with bacterial infections in health and disease with an aim to understand how to prevent and treat infection, thus avoiding the progressive deterioration in lung disease. She is leading an international collaboration to develop and validate tools to monitor disease progression in PCD. Professor Lucas chairs BEAT-PCD (COST Action 1407), coordinating the development of a European research programme to develop and investigate novel treatments for PCD. Translating expertise from PCD to other respiratory diseases Dr Lucas’ laboratories house state-of-the-art equipment for studying ciliated respiratory epithelium including high speed video microscopy, TEM and SEM, with close access to laser scanning confocal microscopes. This enables accurate characterisation of ciliary beat frequency and pattern, and epithelial and ciliary ultra structure. As part of the diagnostic portfolio, her scientific team routinely culture primary epithelial cells on an air liquid interface (ALI), re-differentiating the cilia. Dr Lucas is utilising this expertise and ready access to patient samples in a number of ways. For example: Extending our clinical ALI-culture to a co-culture model which is being used to understand how bacteria interact with the respiratory epithelium in health and disease. The effect of drugs and other extrinsic factors on ciliary function has received little attention. Using the ALI cell culture model the epithelium is treated with extrinsic factors including drugs to measure effect on factors such as ciliary function, inflammatory markers, and epithelial integrity. This model can be used in pre-clinical trials for any drug or molecule under investigation. Allergy and asthma Professor Lucas’s allergy and asthma research program includes understanding the influence of environmental exposures, including diet, during pregnancy and early postnatal life, on lung and immune development. The early life origin of allergic diseases provides a potential to prevent or ameliorate allergic disease. There is currently no cure for food allergy, and patients are required to strictly avoid potential allergens, and carry emergency treatment in case of accidental exposure. Professor Lucas is currently exploring the challenges for people with food allergy and intolerance when purchasing food or eating out.

近期论文

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The international primary ciliary dyskinesia cohort (iPCD Cohort): methods and first results - Goutaki, M., Maurer, E., Halbeisen, F.S., Amirav, I., Barbato, A., Behan, L., Boon, M., Casaulta, C., Clement, A., Crowley, S., Haarman, E., Hogg, C., Karadag, B., Koerner-Rettberg, C., Leigh, M.W., Loebinger, M.R., Mazurek, H., Morgan, L., Neilsen, K.G., Omran, H., Schwerk, N., Scigliano, S., Werner, C., Yiallouros, P., Zivkovic, Z., Lucas, J.S. and Kuehni, C.E. Published:2016Publication:European Respiratory JournalPage Range:1-10doi:10.1183/13993003.01181-2016 Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms - Collins, Samuel A., Kelso, Michael J., Rineh, Ardeshir, Yepuri, Nageshwar R., Coles, Janice, Jackson, Claire L., Halladay, Georgia D., Walker, Woolf T., Webb, Jeremy S., Hall-Stoodley, Luanne, Connett, Gary J., Feelisch, Martin, Faust, Saul N., Lucas, Jane S.A. and Allan, Raymond N. Published:2016Publication:Antimicrobial Agents and ChemotherapyVolume:61, (2)Page Range:e02086-16doi:10.1128/AAC.02086-16PMID:27919896 Diagnostic testing in primary ciliary dyskinesia - Lucas, Jane S., Dimitrov, Borislav D., Behan, Laura and Kuehni, Claudia E. Published:2016Publication:The European Respiratory JournalVolume:48, (3)Page Range:960-961doi:10.1183/13993003.00909-2016 PMID:27581415 ERS Task Force guideline for the diagnosis of primary ciliary dyskinesia - Lucas, J.S., Barbato, A., Collins, S.A., Goutaki, M., Behan, L., Caudri, D., Eber, E., Escudier, E., Hirst, R.A., Hogg, C., Jorrissen, M., Latzin, P., Legendre, M., Leigh, M.W., Midulla, F., Nielsen, K.G., Omran, H., Papon, J.F., Pohunek, P., Redfern, B., Rigau, D., Rindlisbacher, B., Santamaria, F., Shoemark, A., Snijders, D., Tonia, T., Titeni, A., Walker, W.T, Werner, C., Bush, A. and Keuhni, C.E. Published:2016Publication:European Respiratory JournalPage Range:1-54