Lotery, Andrew - University of Southampton

个人简介

He is best known for his genetics research in retinal diseases. He has identified the genetic determinants of retinal diseases and helped to translate these into new therapies such as complement inhibitors for the commonest cause of blindness, age related macular degeneration (AMD). His innovative research in macular disease was recognised internationally by his 2004 election to the United States Macula Society. He is one of the top UK clinician scientists in eye disease as demonstrated by his election as an NIHR senior investigator in 2008 and The Times listing him in their 2010 Top 100 Doctors list. His influential research was recognised by the Royal College of Ophthalmology (RCOphth) who awarded him the Nettleship medal in 2009 for his Lancet paper on AMD genetics. He received the 2012 special award for excellence from the Macular Disease Society and the 2014 University Hospital Southampton Innovation Award. He is editor-in-chief of the Nature publication: Eye since 2008 and former President of the Southern Ophthalmological Society.

研究领域

Andrew is interested in understanding the molecular basis of ophthalmic diseases. His University laboratory identifies genetic determinants of eye disease and studies defined mutations in patient derived induced pluripotent stem cells. New therapeutic approaches are also being explored such as gene therapy and retinal cell transplantation. He also leads a dynamic clinical trials team which has participated in many landmark clinical trials developing new treatments for both common conditions such as age related macular degeneration and also rare conditions such as choroideremia.

近期论文

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Fundus autofluorescence imaging: systematic review of test accuracy for the diagnosis and monitoring of retinal conditions - Frampton, Geoff K., Kalita, Neelam, Payne, Elizabeth, Colquitt, Jillian, Loveman, Emma, Downes, Susan M. and Lotery, Andrew Published:2016Publication:EyePage Range:1-26 The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2) - Taylor-Walker, Georgia, Lynn, Savannah A, Keeling, Eloise, Munday, Rosie, Johnston, David, Page, Anton, Scott, Jennifer A., Goverdhan, Srinivas, Lotery, Andrew J. and Ratnayaka, Janaka Published:2016Publication:Experimental Eye ResearchVolume:153Page Range:110-121doi:10.1016/j.exer.2016.10.013 New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics - Lotery, Andrew, Gibson, Jane and Cree, Angela Published:2016Publication:Human Molecular Genetics Risk of geographic atrophy in age related macular degeneration in patients treated with intravitreal anti-VEGF agents - Gemenetzi, M., Lotery, A.J. and Patel, P.J. Published:2016Publication:EyePage Range:1-9