Johnson, Peter - University of Southampton

个人简介

Peter Johnson graduated from Cambridge University and St Thomas's Medical School. He trained in oncology at St Bartholomew's Hospital, where he was an Imperial Cancer Research Fund Clinical Research Fellow and completed his doctoral research on the Bcl-2 gene, its potential as a therapeutic target in lymphoma and the effects of CD40 ligation on the B-cell surface. He was subsequently a Senior Lecturer in Medical Oncology in the ICRF Cancer Medicine Research Unit, Leeds and took up the Chair of Medical Oncology in Southampton in 1998. He leads the Southampton Cancer Research UK Centre, responsible for bringing together a broad multidisciplinary group of basic, translational and clinical researchers, and linking the laboratory research to the extensive clinical practice in cancer treatment in the Southampton Cancer Centre. Southampton hosts an Experimental Cancer Medicine Centre and a Clinical Trials Unit, both with core support from NIHR and CR UK. He was appointed Chief Clinician for Cancer Research UK in 2008.

研究领域

Peter Johnson specialises in the treatment of lymphoma, and is the Chief Investigator for several lymphoma trials nationally and internationally. He works closely with the immunologists of the academic group, in particular for basic and translational research into the use of immunostimulatory antibodies. He is the Chief investigator in a phase I clinical trial of an agonistic chimerised anti-CD40 antibody which was developed with Martin Glennie's group, and which is being used to test the idea that CD40 ligation may be able to enhance antigen presentation via licencing of professional APCs, while at the same time directing killing of CD40+ tumour cells. His current international trials include the RATHL study in advanced Hodgkin lymphoma, investigating the use of FDG-PET scanning to guide treatment intensification or de-escalation, to optimize the balance between efficacy and toxicity. He also leads the REMoDL-B study, the first to use gene expression profiling in real time to stratify treatment for diffuse large B-cell lymphoma.

近期论文

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IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus - Drennan, S., D'Avola, A., Gao, Y., Weigel, C., Chrysostomou, E., Steele, A.J., Zenz, T., Plass, C., Johnson, P.W., Williams, A.O., Packham, G., Stevenson, F.K., Oakes, C.C. and Forconi, F. Published:2017Publication:LeukemiaPage Range:1-9doi:10.1038/leu.2016.356PMID:27890932 Adapted treatment guided by interim PET scan in advanced Hodgkin’s lymphoma - Johnson, Peter, Federico, Massimo, Kirkwood, Amy, Fossa, Alexander, Berkahn, Leanne , Carella, Angelo, d’Amore, Francesco, Enblad, Gunilla, Franceschetto, Antonella, Fulham, Michael, Luminari, Stefano, O’Doherty, Michael, Patrick , Pip, Roberts, Thomas, Sidra, Gamal, Stevens, Lindsey , Smith, Paul, Trotman, Judith, Viney, Zaid, Radford, John and Barrington, Sally Published:2016Publication:New England Journal of MedicineVolume:374Page Range:2419-2429doi:10.1056/NEJMoa1510093PMID:27332902 Surface IgM expression and function associate with clinical behavior, genetic abnormalities and DNA methylation in CLL - D'Avola, Annalisa, Drennan, Samantha, Tracy, Ian, Henderson, Isla, Chiecchio, Laura, Larrayoz, Marta, Rose-Zerilli, Matthew, Strefford, Jonathan, Plass, Christoph, Johnson, Peter W., Steele, Andrew J., Packham, Graham, Stevenson, Freda K., Oakes, Christopher C. and Forconi, Francesco Published:2016Publication:BloodPage Range:1-25doi:10.1182/blood-2016-03-707786PMID:27301861 IL-4 enhances expression and function of surface IgM in CLL cells - Aguilar-Hernandez, Maria M., Blunt, Matthew, Dobson, Rachel, Yeomans, Alison, Thirdborough, Stephen, Larrayoz, Marta, Smith, Lindsay, Linley, Adam, Strefford, Jonathan C., Davies, Andrew, Johnson, Peter, Savelyeva, Natalia, Cragg, Mark, Forconi, Francesco, Packham, Graham, Stevenson, Freda K. and Steele, Andrew J. Published:2016Publication:BloodPage Range:1-25doi:10.1182/blood-2015-11-682906PMID:27002119