Howarth, Peter - University of Southampton

个人简介

Professor Peter Howarth is Professor of Allergy and Respiratory Medicine and Honorary Consultant Physician with a clinical and research focus on asthma, particularly severe asthma, and allergy. He is Head of the Clinical Studies Forum in the Clinical and Experimental Science (CES) Research division within the Faculty of Medicine, coordinating clinical and translational human based research as well as clinical trials, lead for “Airways disease” within the CES research division and area lead for “Airways disease” within the NIH funded Respiratory Bioscience Research Unit in Southampton. Professor Howarth has funding from the MRC, National Institute of Health Research, EPSRC and Asthma UK as well as Industrial funding for his research that addresses the understanding and treatment of severe asthma. Much of this work makes use of direct airway sampling at bronchoscopy to obtain samples for the evaluation of the airway microbiome, airway inflammatory status, airway remodelling and to obtain samples for ex vivo cell culture studies. Such studies focus, in collaboration, on bronchial epithelial cells, airway mucosal fibroblasts and alveolar macrophages. These approaches have been used both to compare findings in severe asthma to that in healthy controls and mild asthma as well as to evaluate the impact of standard and novel therapeutic approaches to disease management. On-going work also includes biomarker evaluation and evaluation of novel approaches to lung imaging in airways disease. Professor Howarth has supervised over 20 PhD and DM students (scientists and clinicians) and his research involves Local, National and International collaboration. He has participated in EU funded collaborative programmes, such as BIOAIR and GA2LEN, focusing respectively on severe asthma and allergic diseases, and is joint work package 4 lead for UBIOPRED, the EU/EFPIA funded IMI programme on severe asthma. Professor Howarth has published over 200 peer reviewed papers and lectured extensively at National and International specialist society meetings as an invited speaker. Professor Howarth coordinates the MRC funded Wessex Severe Asthma Cohort, a well characterised group of over 300 patients with treatment resistant asthma, established to facilitate basic science and interventional studies in severe asthma. Professorr Howarth is joint lead for the Difficult Airways Service in Southampton, providing a secondary and tertiary referral service for treatment-resistant asthma, and established the Clinical Allergy Service providing a clinical Allergy and Immunology service for the Wessex region. This close patient involvement provides the basis for the translational research programme and the appreciation of the unmet clinical needs. Professor Howarth is regional advisor on allergy training and a member of the standing advisory committee for Allergy and Immunology at The Royal College of Physicians. Professor Howarth has contributed to National, European and International (World Health Organisation) guidelines on the management of rhinitis and asthma. He has been on the council of The British Society of Allergy and Clinical Immunology, advisor on allergy to Asthma UK and has been chairman of the board of trustees of Allergy UK. He is currently President of Allergy UK and a trustee of AAIR.

研究领域

My research is focused on the pathophysiology and pharmacology of airways disease This research is aimed at better understanding the pathophysiology of clinical disease expression, the impact of current and novel therapies on the disease process and the identification of biomarkers to aid in diagnosis, disease monitoring and in early phase clinical trials as surrogate end-points.

近期论文

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Airway and peripheral uPAR is elevated in asthma, and identifies a severe, non-atopic subset of patients - Portelli, Michael A., Moseley, Christopher, Stewart, Ceri E., Postma, Dirkje S., Howarth, Peter, Warner, Jane A., Holloway, John Q., Koppelman, Gerard H., Brightling, Chris and Sayers, Ian Published:2016Publication:AllergyPage Range:1-10doi:10.1111/all.13046 Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life - Davies, Elizabeth R., Kelly, Joanne F., Howarth, Peter H., Wilson, David, Holgate, Stephen, Davies, Donna E., Whitsett, Jeffrey A. and Haitchi, Hans Michael Published:2016Publication:Journal of Clinical Investigation InsightVolume:1, (11)Page Range:1-16doi:10.1172/jci.insight.87632 IL-1alpha mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit - Hill, Alison R., Donaldson, Jess E., Blume, Cornelia, Smithers, Natalie, Tezera, Liku, Tariq, Kamran, Dennison, Patrick, Rupani, Hitasha, Edwards, Matthew J., Howarth, Peter H., Grainge, Chris, Davies, Donna E. and Swindle, Emily J. Published:2016Publication:Tissue BarriersVolume:4, (3)Page Range:1-12doi:10.1080/21688370.2016.1206378 Mechanical strain causes adaptive change in bronchial fibroblasts enhancing profibrotic and inflammatory responses - Manuyakorn, Wiparat, Smart, David, Bucchieri, Fabio, Haitchi, Hans, Holgate, Stephen, Howarth, Peter and Davies, Donna Published:2016Publication:PLoS ONEVolume:11, (4)Page Range:1-16doi:10.1371/journal.pone.0153926PMID:27101406