Hossain, Parwez - University of Southampton

个人简介

Parwez qualified in Medicine from Aberdeen University and trained in Ophthalmology in Aberdeen, Nottingham, Leicester & Bascom Palmer Eye Institute, Miami, USA. He sub-specialises in Cornea & External Eye Disease. In 2005, he was appointed as Senior Lecturer in Ophthalmology / Consultant Ophthalmologist at Southampton University & Southampton General Hospital. Parwez's clinician-scientist career started at Aberdeen University where he was awarded a Wellcome Trust Fellowship to study the mechanisms of lymphocyte traffic in ocular inflammation. In his PhD thesis, he established a novel method for in vivo tracking of immune cells in the retina and choroid. The technique allowed the early interactions of lymphocytes with an inflamed vascular endothelium to be observed and quantified. Allowing the role of different adhesion molecules involved in lymphocyte-endothelium to be assessed. Following his PhD, Parwez was appointed Clinical Lecturer at Nottingham University; there his interest focused on investigating the innate immune mechanisms during corneal inflammation. He found that the immune adhesion molecule CD34 is a unique marker for human corneal stromal keratocyte (corneal fibroblast) activation. He noted that this immune marker was dysregulated during corneal inflammatory disease and keratocyte CD34 expression distinguished ‘resting’ and ‘activated’ keratocytes in the human eye.

研究领域

Currently, Parwez’s research activity is focused finding new approaches to manage corneal disease. Host-Pathogen Interactions in Human Bacterial Keratitis Corneal infections are a major cause of visual impairment worldwide. In the UK alone, 6000 patients are affected from corneal microbial infections every year. Bacterial organisms such Pseudomonas aeroginosa are major causative agents in pathogenesis. Visual impairment often is very rapid (within 24 hours) and frequently leads to permanent visual loss (Figure 1). A common problem during such infection is the severe levels of corneal tissue damage. We know from animal models, that this results from the combined effects from the actions of the pathogen and the host’s inflammatory process. The cornea quickly loses its normal transparency, leading to visual impairment. Since the cornea is a thin structure (human central cornea thickness is only 550μm), tissue damage carries high risks of ocular perforation and visual loss. Although antimicrobial therapies are usually successful in reducing the pathogen load, they do not help to limit tissue damage. Currently, there is no effective treatment to limit this. Such therapies are highly desirable since patients would benefit from reduced effects of uncontrolled tissue damage. Parwez has set-up a clinical and laboratory investigative programme, to investigate how different pathogens interact with the human cornea. Collaborating with other groups in the University with expertise in molecular microbiology, tissue culture and leukocyte biology, he has developed, an ex vivo human explant tissue model to understand the early events in cornea-pathogen interaction. Parwez’s group has recently found that activation of Pathogen Recognition Receptors (Toll-like Receptors (TLRs)) in patients with gram negative corneal infection, profoundly influence the ability of corneal stromal cells to produce pro-inflammatory cytokines such as interleukin-1beta, IL-8, IL-6, as well as, tissue degradative enzymes like matrix metalloproteinases (MMPs) and undergo TLR-4 mediated apoptosis (Figure 2). Parwez uses his clinical practice to collect patient samples with severe corneal inflammatory disease. His clinical service serves a large referral base of approximately 2 million patients coming from Hampshire, Isle of Wight & the Channel Islands. With his NHS colleagues, he runs one of the busiest centers for corneal transplantation in the UK. This arrangement complements his laboratory studies, where he requires a steady supply of human corneal tissue for his explant models. These laboratory investigations are structured so that new drugs can be assessed for their effectiveness in combating these effects.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - response. - Tsatsos, M., MacGregor, C., Athanasiadis, I., Moschos MM, M.M. and Hossain, P. Published:2016Publication:Journal of Clinical & Experimental OphthalmologyPage Range:1-3doi:10.1111/ceo.12835PMID:27635860 Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and topical antiviral agents - Tsatsos, Michael, MacGregor, Cheryl, Athanasiadis, Ioannis, Moschos, Marilita M., Hossain, Parwez and Anderson, David Published:2016Publication:Clinical & Experimental OphthalmologyPage Range:1-38doi:10.1111/ceo.12785PMID:27273328 Determinants of visual quality after endothelial keratoplasty - Trunbull, Andrew M.J., Tsatos, Michael, Hossain, Parwez and Anderson, David Published:2015Publication:Survey of OphthalmologyPage Range:1-27doi:10.1016/j.survophthal.2015.12.006PMID:26708363 Recent trends of human wellbeing in the Bangladesh delta - Hossain, Md Sarwar, Amoako Johnson, Fiifi, Dearing , John A. and Eigenbrod, Felix Published:2015Publication:Environmental Development Volume:17Page Range:21-32doi:10.1016/j.envdev.2015.09.008