Haitchi, Hans Michael - University of Southampton

研究领域

Dr. Haitchi’s research focuses on chronic lung diseases, such as asthma, COPD, cystic fibrosis, which are a major burden on the healthcare system in the UK and worldwide. Many of these diseases originate early in life by an interaction between parental genetic and environmental factors (e.g. maternal allergy & smoking) before birth and in infancy. From epidemiological studies it is known that these early interactions predict if somebody develops a chronic lung disease later in life, however very little is known about the exact mechanisms or how this occurs. By exploring these mechanisms his ultimate aim is to find and develop novel therapies that act early as well as later in life.

近期论文

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Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life - Davies, Elizabeth R., Kelly, Joanne F., Howarth, Peter H., Wilson, David, Holgate, Stephen, Davies, Donna E., Whitsett, Jeffrey A. and Haitchi, Hans Michael Published:2016Publication:Journal of Clinical Investigation InsightVolume:1, (11)Page Range:1-16doi:10.1172/jci.insight.87632 Mechanical strain causes adaptive change in bronchial fibroblasts enhancing profibrotic and inflammatory responses - Manuyakorn, Wiparat, Smart, David, Bucchieri, Fabio, Haitchi, Hans, Holgate, Stephen, Howarth, Peter and Davies, Donna Published:2016Publication:PLoS ONEVolume:11, (4)Page Range:1-16doi:10.1371/journal.pone.0153926PMID:27101406 Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients - Hoffmann, Julia, Marsh, Leigh M., Pieper, Mario, Stacher, Elvira, Ghanim, Bahil, Kovacs, Gabor, König, Peter, Wilkens, Heinrike, Haitchi, Hans Michael, Hoefler, Gerald, Klepetko, Walter, Olschewski, Horst, Olschewski, Andrea and Kwapiszewska, Grazyna Published:2015Publication:AJP Lung Cellular and Molecular PhysiologyVolume:308, (10)Page Range:L1002-L1013doi:10.1152/ajplung.00383.2014PMID:25840998