Garbis, Spiros D - University of Southampton

个人简介

Dr. Spiros D. Garbis is an Associate Professor for the Faculty of Medicine and Head of Clinical Mass Spectrometry group for the Cancer Sciences Academic Unit. Dr. Garbis has USA industrial and forensic analytical toxicology experience and since his fulltime return to academia in 2004, he has been pivotal to the development and application of mass spectrometry proteomics and metabolomics methods in the discovery and validation of candidate biomarkers with potential clinical utility for the early diagnosis of cancer, cardiovascular and neurodegenerative disease linked to metabolic syndrome. A key theme of his research is to understand gene-nutrient interactions at the endophenotypic protein and metabolite level with the use of stable isotope tracer approaches in cell culture, animal models, and humans. Therefore, the inquiry on the functional interplay between spontaneous mutations of nutrient or pharmacologic receptors and their enzyme substrates may contribute to metabolic syndrome and derivative communicative (HIV and Tuberculosis) and non-communicative (cardiovascular, neurodegenerative and cancer) disease states.

研究领域

The principle goal of the Dr. S.D.Garbis team is to develop a cost-effective blood based surveillance, screening and detection strategy to identify and monitor high-risk cancer populations at an early, asymptomatic stage. This effort entails the development of protein-level evidence risk prediction models based on cancer control studies, epidemiological data and validated biomarkers that can be used routinely in a clinical laboratory setting. Types of cancer biomarkers currently under development by Dr. Garbis include disease progression from the benign to the aggressive / metastatic stage, response to pharmacologic treatment response (therapeutic or chemopreventive), and nutritional intervention (i.e., omega-3 fatty acid and Vitamin D status correction/optimization). A key research theme of Dr. Garbis is the better understanding on how the metabolic syndrome (Obesity, type-2 Diabetes, Non-alcoholic liver disease, elevated serum triglyceride levels, etc.) is causally implicated in certain forms of cancer (breast, colon, pancreatic, and prostate). The principle research aims of Dr. S. D. Garbis include: The discovery and validation of novel biomarker panels, as unique “chemical signatures” for the asymptomatic prediction, diagnosis and prognosis of solid tumor cancers at the serum or plasma level (i.e. breast, prostate, ovarian and esophageal) Pharmacoproteomics and Interactomics approaches in the investigation of mechanisms of drug action and biomarkers of treatment response (pharmacodynamic markers). In this capacity, the temporal and multi-focal effects of candidate drugs to whole, systems-wide proteomes are investigated. Additionally, the initiating ligand-protein interactions are interrogated with custom chemical affinity chromatographic probes. Targeted protein-protein interaction profiling is assessed with chemical cross-linkers Role of nutrition in metabolic syndrome disease and its potential role to the chemoprevention of cancer. The key role of DNA damage to nutrient metabolizing enzymes and its effect to sub-clinical deficiencies of essential nutrients (i.e. Folate, Vitamin D and n-3 fatty acids). The proteomics driven targeted analysis of primary metabolites such as co-factors and amino acids is used for the functional annotation of the enzymes implicated in their biosynthesis The development of lab-on-a-chip devices for advanced proteomic analysis applications, including the targeted quantitative LC-MS analysis of candidate protein biomarkers (LabChip-SRM MS-MS)

近期论文

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Integrated cellular and plasma proteomics of contrasting B-cell cancers reveals common, unique and systemic signatures - Johnston, Harvey, Carter, Matthew, Cox, Kerry, Dunscombe, Melanie, Manousopoulou, Antigoni, Townsend, Paul, Garbis, Spiros and Cragg, Mark Published:2017Publication:Molecular & Cellular ProteomicsPage Range:1-39doi:10.1074/mcp.M116.063511PMID:28062796 Sex specific vitamin D effects on blood coagulation among overweight adults - Al-Daghri, Nasser M., Alokail, Majed S., Manousopoulou, Antigoni, Heinson, Ashley, Al-Attas, Oman, Al-Saleh, Yousef, Sabico, Shaun, Yakout, Sobhy, Woelk, Christopher H., Chrousos, Geroge P. and Garbis, Spiros D. Published:2016Publication:European Journal of Clinical InvestigationPage Range:1-22doi:10.1111/eci.12688PMID: 27727459 Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study - Larkin, S.E.T., Johnston, H.H., Jackson, T.R., Jamieson, D.G., Roumeliotis, T.I., Mockridge, C.I., Michael, A., Manousopoulou, A., Papachristou, E.K., Brown, M.D., Clarke, N.W., Pandha, H., Aukim-Hastie, C.L., Cragg, M.S., Garbis, S.D. and Townsend, P.A. Published:2016Publication:British Journal of Cancerdoi:10.1038/bjc.2016.291PMID:27685442