Feelisch, Martin - University of Southampton

个人简介

After the study of pharmacy Martin earned his PhD in pharmacology from the Heinrich-Heine University in Dusseldorf in 1988. He was appointed to the Personal Chair of Experimental Medicine & Integrative Biology at Southampton University in April 2012, following a number of other senior research positions in both academia and industry in the USA and Europe. Qualifications BSc/MSc (Diploma), Pharmacy, Heinrich-Heine University, Dusseldorf, 1985 PhD (summa cum laude), Pharmacology, Heinrich-Heine University, 1988 Specialist for Drug Information, Apothekerkammer Nordrhein, 1992 Expert in Pharmacology, German Society for Experimental & Clinical Pharmacology and Toxicology (DGPT), 1992 Habilitation (venia legendi), Pharmacology and Toxicology, University of Cologne, 1997

研究领域

Martin has a long-standing interest in analytical chemistry, cardiovascular pharmacology, nutrition and metabolism, photobiology, disease mechanisms, and the chemical biology of nitric oxide (NO), nitroxyl (HNO), and sulfide in its various forms (H2S, HS-, R-SSxH). His more recent interests focus on the interconversion of nitrogen and sulfur species and related storage forms in the context of intermediary metabolism, the role of sunlight and the skin microbiome for cardiovascular health, mechanisms of adaptation to hypoxia and altitude as well as the significance of chemical interactions between reactive oxygen, nitrogen and sulfur species (ROS, RNS, RSS) for mitochondrial function and redox signalling in humans. Work in his laboratory is both hypothesis- and curiosity-driven and includes basic as well as translational research projects in all of the above areas. Current development efforts in his lab focus on targeted metabolomic approaches (‘redox metabolomics’) to disentangle the mechanisms of redox regulation in health and disease.

近期论文

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Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms - Collins, Samuel A., Kelso, Michael J., Rineh, Ardeshir, Yepuri, Nageshwar R., Coles, Janice, Jackson, Claire L., Halladay, Georgia D., Walker, Woolf T., Webb, Jeremy S., Hall-Stoodley, Luanne, Connett, Gary J., Feelisch, Martin, Faust, Saul N., Lucas, Jane S.A. and Allan, Raymond N. Published:2016Publication:Antimicrobial Agents and ChemotherapyPage Range:1-16doi:10.1128/AAC.02086-16PMID:27919896 Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner - Roggenbuck, Michael, Anderson, Denise, Barfod, Kenneth Klingenberg, Feelisch, Martin, Geldenhuys, Sian, Sørensen, Søren J., Weeden, Clare E., Hart, Prue H. and Gorman, Shelley Published:2016Publication:Respiratory ResearchVolume:17, (116)Page Range:1-18doi:10.1186/s12931-016-0435-3 Nitrosopersulfide (SSNO(-)) targets the Keap-1/Nrf2 redox system. - Cortese-Krott, Miriam M., Pullmann, David and Feelisch, Martin Published:2016Publication:Pharmacological ResearchPage Range:1-44doi:10.1016/j.phrs.2016.09.022PMID:27663261 Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp - Hennis, Philip J., Mitchell, Kay, Gilbert-Kawai, Edward, Bountziouka, Vassiliki, Wade, Angie, Feelisch, Martin, Grocott, Michael P. and Martin, Daniel S. Published:2016Publication:Nitric OxideVolume:60Page Range:24-31doi:10.1016/j.niox.2016.08.007PMID:27593617