Fall, Caroline - University of Southampton

个人简介

Caroline Fall studied medicine at the University of Bristol, followed by clinical training in General Medicine, General Practice and Paediatrics. She joined the MRC Environmental Epidemiology Unit in 1989, to study the Hertfordshire cohort, and showed that low birthweight and infant weight were associated with an increased risk of insulin resistance and Type 2 diabetes in adult life. Since 1993, she has been working on the fetal origins of diabetes mainly in Indian populations, building up collaborations in several centres in India. Caroline Fall works with a team of epidemiologists and statisticians investigating the fetal origins of cardiovascular disease and Type 2 diabetes and the maternal factors influencing fetal growth. Her chief role is to co-ordinate a programme of research involving 5 centres in India. These studies include the follow-up of children and adults whose size at birth was recorded, and more recently, prospective studies on the short and long-term effects on the offspring of maternal nutritional status and glucose/insulin metabolism. She was the moving force and organising secretary for the First World Congress on the Fetal Origins of Adult Disease held in Mumbai, India, February 2001, and a member of the scientific planning committees for the Third and Sixth World Congresses, held in Toronto (November 2005) and Santaigo, Chile (November 2009). She is secretary of the International Society for the Developmental Origins of Health and Disease (DOHaD)and Associate Editor of the newly launched Journal of Developmental Origins of Health and Disease.

研究领域

Developmental origins of type 2 diabetes and Metabolic Syndrome Maternal nutrition and metabolism – effects on fetal growth and later health Childhood growth patterns and later disease Research objective: Translating the Developmental Origins of Health and Disease (DOHaD) concept into interventions to improve human health and prevent disease in developing countries. Prof Fall joined Professor David Barker’s research group as a British Heart Foundation research fellow in 1989. She studied cardiovascular disease risk factors, glucose/insulin metabolism and LV mass among men and women from the Hertfordshire birth cohort, the first studies linking type 2 diabetes to low birthweight. Subsequent studies of 24-hour growth hormone and cortisol profiles provided evidence that early life effects on later health are mediated by the programming of endocrine axes. In 1991, Prof Fall initiated a programme of DOHaD research in India, which now encompasses work with collaborative groups in Mumbai, Pune, Delhi, Mysore and Vellore. Studies include birth cohort studies, prospective studies of maternal nutrition and metabolism in pregnancy, and intervention trials of nutritional supplementation before and during pregnancy.

近期论文

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Weight gain and height growth during infancy, childhood and adolescence as predictors of adult cardiovascular risk markers in South Asian Indians - Antonisamy, B., Vasan, S.K., Geethanjali, F.S., Gowri, S., Hepsy, F.S., Richard, J., Raghupathy, P., Karpe, F., Osmond, Clive and Fall, Caroline Published:2016Publication:Journal of PediatricsPage Range:1-20 Commentary: Disentangling the contributions of childhood and adult weight to cardiovascular disease risk - Fall, C., Victora, C., Eriksson, J.G. and Osmond, C. Published:2016Publication:International Journal of EpidemiologyPage Range:1-6doi:10.1093/ije/dyw157 PMID:27498298