Evans, Nicholas - University of Southampton

个人简介

Nick was appointed as a lecturer in Bioengineering at Southampton University in January 2011. He holds a dual appointment between the Faculty of Engineering and the Environment and the Faculty of Medicine, where he is based in the Centre for Human Development, Stem Cells and Regenerative Medicine. He completed a PhD at King's College under the supervision of Prof John Pickup, where he researched techniques in fluorescence spectroscopy for tracking metabolism in cells by using their natural fluorescence. After experiencing some of the excitement of stem cell biology, he worked as an MRC postdoctoral fellow at Imperial College researching the effects of extracellular matrix on the differentiation of embryonic stem cells. He then took a postdoctoral position at Stanford University to study how a molecular pathway, called the Wnt signalling pathway, could be used to promote wound healing, before his appointment at Southampton. He now leads a research team working on several aspects of regenerative medicine relating to bone and skin, and collaborates with a number of other researchers in the UK and Europe.

研究领域

Nick leads a team investigating how materials, compounds and stem cells can be used to promote tissue regeneration in bone and skin disease and injury. Wnt in tissue regeneration Wnt growth factors are some of the most ancient known signalling proteins. They're found throughout the animal kingdom - from sponges to man - and play fundamental roles in animal development and disease. The molecular pathways that Wnt proteins activate also regulate stem cell division, and can sometimes promote tissue regeneration in animals such as amphibians. We're investigating whether we can promote tissue regeneration in mammals, particularly in the skin and bone, by chemically modulating Wnt signalling. To achieve this, we’re trying to selectively deliver proteins and other molecules that change Wnt signalling specifically to stem cells, particularly in the bone.

近期论文

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Nanoanalytical electron microscopy reveals a sequential mineralization process involving carbonate-containing amorphous precursors - Nitiputri, Kharissa, Ramasse, Quentin M., Autefage, Helene, McGilvery, Catriona M., Boonrungsiman, Suwimon, Evans, Nicholas D., Stevens, Molly M. and Porter, Alexandra E. Published:2016Publication:ACS NanoVolume:10, (7)Page Range:6826-6835doi:10.1021/acsnano.6b02443PMID:27383526 Quantification of intracellular payload release from polymersome nanoparticles - Scarpa, Edoardo, Findlay, Joanne, Stumpf, Patrick, Johnston, Alexander, Oreffo, Richard, Woo, L.Y., Cheong, Ying, Evans, Nick and Newman, Tracey Published:2016Publication:Scientific ReportsPage Range:1-36 Quantification of intracellular payload release from polymersome nanoparticles - Scarpa, Edoardo, Bailey, Joanne, Janeczek, Agnieszka, Stumpf, Patrick, Johnston, Alexander, Oreffo, Richard, Woo, Yin L., Cheong, Ying, Evans, Nick and Newman, Tracey Published:2016Publication:NaturePage Range:1-36 Transient canonical Wnt stimulation enriches human bone marrow mononuclear cell isolates for osteoprogenitors - Janeczek, Agnieszka A., Tare, Rahul S., Scarpa, Edoardo, Moreno-Jimenez, Ines, Rowland, Caroline A., Jenner, Dominic, Newman, Tracey A., Oreffo, Richard O.C. and Evans, Nicholas D. Published:2015Publication:Stem CellsPage Range:1-13doi:10.1002/stem.2241PMID:26573091