Elliott, Tim - University of Southampton

个人简介

Professor Tim Elliott left the University of Oxford with a first in Biochemistry in 1983, received a PhD from the University of Southampton in 1986 and completed his postdoctoral training at MIT. He held a lectureship and later a professorship in immunology (Weatherall Institute for Molecular Medicine and Balliol College, University of Oxford) between 1990-2000 before being appointed to the Chair of Experimental Oncology, School of Medicine, University of Southampton. He was Associate Dean (Research) for the Faculty of Medicine between 2005 and 2015. He’s held appointments on Scientific Advisory boards at the Wellcome Trust, the Association of International Cancer Research, Leukaemia and Lymphoma Research, and Symphogen, and currently chairs the CRUK Expert Review Group for Cancer Immunology He has published over 130 papers (h-index, 48) in the field of molecular immunology; was visiting lecturer of the Alberta Heritage Foundation for Medical Research, University of Edmonton, Alberta in 1999; and recently held a visiting Professorship at the Netherlands Cancer Institute, Amsterdam. He is a fellow of the Royal Society of Biology and in 2014 he was elected to the Academy of Medical Sciences.

研究领域

Cytotoxic T cells (CTL) are an important arm of our immune defence against intracellular pathogens such as viruses, bacteria and parasites and can provide protection against the development of tumours. The picture to the right shows a swarm of CTL (coloured in white) attacking a tumour cell (coloured in orange). The outcome of this attack will be the destruction of the tumour cell. CTL recognise fragments of protein antigens (epitopes), derived from pathogens or tumours, bound to polymorphic receptor molecules encoded by the Major Histocompatibility Complex (class I) on the surface of infected cells. The process of generating peptide fragments from pathogen proteins is known as antigen processing, and the formation of a complex, between these peptides and MHC class I molecules, which can be seen by circulating CTL is known as antigen presentation. It is the point where these two processes meet that has occupied me over the past ten years. Here, polypeptide fragments containing CTL epitopes are transported from the cytosol, where they are made, into the endoplasmic reticulum (ER) where MHC class I molecules are synthesised. This requires a specialised peptide transporter - the Transporter Associated with Antigen Processing or TAP. Once in the ER the polypeptide fragments can be trimmed to an optimal size for binding to newly synthesised MHC class I molecules by an aminopeptidase called ERAP. A process of molecular editing follows in order to ensure that only the most stable peptide:MHC complexes are released to the cell surface.

近期论文

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The clonal iNKT cell repertoire in people with type 1 diabetes is characterized by a loss of clones expressing high-affinity T cell receptors - Tocheva, Anna S., Mansour, Salah, Holt, Tristan G.H., Jones, Samuel, Chancellor, Andrew, Sanderson, Joseph P., Eren, Efrem, Elliott, Timothy, Holt, Richard and Gadola, Stephan Published:2016Publication:The Journal of ImmunologyPage Range:1-25 Bone marrow transplantation for MHC class I deficiency corrects T cell immunity but dissociates NK cell repertoire formation from function - Gao, Yifang, Arkwright, Peter D., Darley, Rachel, Cazaly, Angelica, Harrison, Rebecca J., Mant, Alexandra, Cant, Andrew J., Gadola, Stephan, Elliott, Timothy, Khakoo, Salim and Williams, Anthony Published:2016Publication:Journal of Allergy and Clinical ImmunologyPage Range:1-16doi:10.1016/j.jaci.2016.06.029 Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells - Mansour, Salah, Tocheva, Anna S., Cave-Ayland, Christopher, Machelett, Moritz M., Sander, Barbara, Lissin, Nikolai M., Molloy, Peter E., Baird, Mark S., Stübs, Gunthard, Schröder, Nicolas W.J., Schumann, Ralf R., Rademann, Jörg, Postle, Anthony D., Jakobsen, Bent K., Marshall, Ben G., Gosain, Rajendra, Elkington, Paul T, Elliott, Timothy, Skylaris, Chris-Kriton, Essex, Jonathan W., Tews, Ivo and Gadola, Stephan D. Published:2016Publication:Proceedings of the National Academy of SciencesVolume:113, (9)Page Range:E1266-E1275doi:10.1073/pnas.1519246113PMID:26884207