Elkington, Paul - University of Southampton

个人简介

Professor Elkington trained in medicine at Oxford and then worked in various London teaching hospitals, in addition to Zambia, and completed his training in respiratory and general medicine in 2007. His research into lung destruction in tuberculosis started in Jon Friedland’s group at Imperial College London with a Wellcome Trust Clinical research training fellowship (2002 – 2005), followed by a NIHR Clinician Scientist Award (2006 – 2011), and then a HEFCE Clinical Senior Lecturer Award (2011 - 2016). He moved to Southampton University in June 2012 to develop a research programme centred on the role of proteases in the pathology of pulmonary infection. Current active funding is from HEFCE, US NIH, PHE, EPSRC, Colciencias and the MRC. Professor Elkington is a member of NAMRIP, the University’s Network for Antimicrobial Resistance and Infection Prevention strategic research group.

研究领域

My research interest is how airborne pathogens cause damage to patients' lungs, primarily focusing on tuberculosis. Tuberculosis continues to kill almost 1.5 million people a year in the developing world, and lung disease not only causes spread from person to person but also causes most mortality and morbidity. Our research approach is to integrate analysis of clinical samples with bioengineering techniques to understand the mechanisms of disease. My research focuses on how enzymes called matrix metalloproteinases drive lung cavitation to develop new diagnostic and therapeutic approaches. TB diagnosis in the developing world relies on a technique 100 years old and TB treatment has remained unchanged for the last 30 years. We have shown that tuberculosis up-regulates multiple proteases, in particular MMP-1, which degrades collagen fibers within the lung. These proteases are suppressed in advanced HIV infection, explaining why these patients do not develop lung cavitation.

近期论文

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Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model - Tezera, Liku B., Bielecka, Magdalena K., Chancellor, Andrew, Reichmann, Michela T., Al Shammari, Basim, Brace, Patience, Batty, Alex, Tocheva, Anna, Jogai, Sanjay, Marshall, Ben G., Tebruegge, Marc, Jayasinghe, Suwan N., Mansour, Salah and Elkington, Paul T. Published:2017Publication:eLifePage Range:1-47doi:10.7554/eLife.21283 Tuberculosis: an infection-initiated autoimmune disease? - Elkington, Paul, Tebruegge, Marc and Mansour, Salah Published:2016Publication:Trends in ImmunologyPage Range:1-3doi:10.1016/j.it.2016.09.007PMID:27773684 Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases - Ostridge, Kristoffer, Williams, Nicholas, Kim, Viktoriya, Harden, Stephen, Bourne, Simon, Coombs, Ngaire A., Elkington, Paul T., Estepar, Raul San Jose, Washko, George, Staples, Karl J. and Wilkinson, Tom M.A. Published:2016Publication:Respiratory ResearchVolume:17, (92)Page Range:1-8doi:10.1186/s12931-016-0402-zPMID:27460105 Hypoxia and tissue destruction in pulmonary tuberculosis - Belton, M., Brilha, S., Manavaki, R., Mauri, F., Nijran, K., Hong , Y.T., Patel, N., Dembek, M., Tezera, L., Green, J., Moores, R., Aigbirhio, F., Al-Nahtas, A., Fryer, T.D., Elkington, P. and Friedland, J.S. Published:2016Publication:ThoraxPage Range:1-44