Edwards, Christopher - University of Southampton

个人简介

Professor Edwards is a clinical rheumatologist with research interests and expertise in the epidemiology and treatment of inflammatory rheumatic diseases including rheumatoid arthritis, lupus, psoriatic arthritis and ankylosing spondylitis. He attended medical school at King's College London and trained at the Hammersmith and St George's Hospitals in London. He was a registrar for Professor Graham Hughes at the St Thomas' Hospital lupus unit and then undertook a period of research as a lecturer at the Kennedy Institute of Rheumatology at Imperial College under the supervision of Professor Ravinder Maini. He moved to Southampton in 2001 after working for a year as a rheumatology consultant at Tan Tock Seng Hospital in Singapore. He is a member of international committees working to produce guidelines for the best management of rheumatic diseases, leading a systematic review of guidelines for the use of radiology in the diagnosis and management of rheumatoid arthritis for the European League Against Rheumatism (EULAR). With expertise in the planning and delivery of trials in this area, including early stage trials, Professor Edwards has developed strong local and international partnerships with clinical and academic colleagues, centred on his role as clinical lead of the Southampton Musculoskeletal Research Unit.

研究领域

Epidemiology of inflammatory rheumatic diseases Professor Edwards’ current research focusses on understanding the causes of inflammatory rheumatic diseases including lupus and rheumatoid arthritis. He is also working on projects looking at the epidemiology of rheumatoid arthritis and the predictors of joint replacement in inflammatory rheumatic diseases as an honorary senior research fellow at the University of Oxford. He leads a research programme investigating RA that has provided new epidemiological insights into the treatment of RA within the UK and identified regional differences in disease modifying drugs use. Further studies have explored the increased prevalence of cardiovascular disease (CVD) in individuals with RA including the discovery that the presence of rheumatoid factor (RF) in the general population is associated with an increased risk of CVD. They have shown that early life factors may influence the likelihood of developing the autoantibodies RF and antinuclear antibodies in later life. Trials of new immunotherapies Professor Edwards is Chief and Principal investigator for several trials of biological therapies for the treatment of RA, SLE, psoriatic arthritis and AS including phase 1 and complex later phase work. He advises the pharmaceutical industry on the development of trials in this area.

近期论文

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The prevalence of self-reported lower limb and foot health problems experienced by participants with systemic lupus erythematosus: Results of a UK national survey - Cherry, L., Alcacer-Pitarch, B., Hopkinson, N., Teh, L.S., Vital, E.M., Edwards, C.J., Blake, A. and Williams, A.E. Published:2016Publication:LupusPage Range:1-13 A pilot investigation of the prevalence of US-detectable forefoot joint pathology and reported foot-related disability in participants with systemic lupus erythematosus - Mukherjee, Sandeep, Cherry, Lindsey, Zarroug, Jalaa, Culliford, David, Bowen, Catherine, Arden, Nigel and Edwards, Christopher Published:2016Publication:Journal of Foot and Ankle ResearchPage Range:1-6doi:10.1186/s13047-016-0158-1 Biologic dose reduction in rheumatoid arthritis: what do patients think? Results from a patient and public involvement event - Wallis, Dinny, Holroyd, Chris, Sonpal, Kate, Zarroug, Jalaa, Adams, Jo and Edwards, Chris Published:2016Publication:RheumatologyVolume:55Page Range:i187-i187doi:10.1093/rheumatology/kew166.006 An exploration of the characteristics of early RA hand involvement among different gender, age, and hand-dominance in a Chinese population - Bowen, Su, Qing, Ma, Edwards, Christopher J., Williams, Mark and Adams, Jo Published:2016Publication:RheumatologyVolume:55Page Range:i113doi:10.1093/rheumatology/kew130.009