Eccles, Diana - University of Southampton

个人简介

Professor Eccles has been Chair of Cancer Genetics since 2004. She graduated from Manchester University on 1983 and has trained in Manchester, Edinburgh and Southampton. After training in general medicine, then specialist training in adult oncology she worked on the molecular genetics of ovarian cancer in the MRC Human Genetics Unit in Edinburgh to gain her MD in 1992. She then moved to Southampton to a research post in Genetic Epidemiology simultaneously training in Clinical Genetics and when appointed to a consultant post in Southampton in 1995 she set up one of the first NHS funded Cancer Genetics Services in the UK within the Wessex Clinical Genetics Service. Professor Eccles is the Chief Investigator for a large national cohort study (the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer). This study has recruited over 3000 women with breast cancer diagnosed before 41 years of age and provides material for studies investigating the role of inherited genetic mutation in breast cancer risk and prognosis. She is PI for a number of other clinical studies that broadly aim to improve diagnosis or management of genetic predisposition to cancer and incorporates cancer prevention studies. Professor Eccles is the Head of the Cancer Sciences Academic Unit which incorporates the Southampton Cancer Research UK Centre, the Southampton Clinical Trials Unit and links closely through our clinical academics to Cancer Care at UHS (http://www.southampton.ac.uk/medicine/research/groups/cancer_sciences_research_group.page). She continues to work as an NHS consultant in clinical cancer genetics which encompasses diagnosis and management of many different genetic conditions that predispose to tumour development in families.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci - Kar, Siddhartha, Adler, Emily, Tyrer, Jonathan, Hazelett, Dennis, Anton-Culver, Hoda, Bandera, Elisa, Beckmann, Matthias, Berchuck, Andrew, Bogdanov, Natalia, Brinton, Louise, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Cook, Linda, Cramer, Daniel, Cunningham, Julie, Dansonka-Mieszkowska, Agnieszka, Doherty, Jennifer, Dork, Thilo, Durst, Matthias, Eccles, Diana, Fasching, Peter and Flanagan, James Published:2016Publication:British Journal of Cancer Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers - Kuchenbaecker, Karoline and Eccles, Diana Published:2016Publication:JNCI Journal of the National Cancer InstitutePage Range:1-59 Local recurrence and breast oncological surgery in young women with breast cancer: the POSH observational cohort study - Maishman, Thomas, Cutress, Ramsey, Hernandez, Aurea, Gerty, Susan, Copson, Ellen, Durcan, Lorraine and Eccles, Diana Published:2016Publication:Annals of SurgeryPage Range:1-8doi:10.1097/SLA.0000000000001930PMID:27455160 Information requirements of young women with breast cancer treated with mastectomy or breast conserving surgery: a systematic review - Recio-Saucedo, Alejandra, Gerty, Sue, Foster, Claire, Eccles, Diana and Cutress, Ramsey I. Published:2016Publication:The BreastVolume:25Page Range:1-13doi:10.1016/j.breast.2015.11.001PMID:26801410 Genetic testing in a cohort of young patients with HER2 amplified breast cancer - Eccles, D.M., Li, N., Handwerker, R., Maishman, T., Copson, E.R., Durcan, L.T., Gerty, S.M., Jones, L., Evans, D.G., Haywood, L. and Campbell, I. Published:2015Publication:Annals of OncologyPage Range:1-20