Dawson, Jonathan - University of Southampton

个人简介

Jon started his work with clay nanoparticles during his PhD (2004-2007), investigating novel biomaterials for skeletal regeneration. The PhD was a BBSRC Strategic Research Studentship at the interface of medicine and chemistry under Prof. Richard Oreffo (School of Medicine, University of Southampton, USOTON) and Prof. George Attard (School of Chemistry, USOTON). The work was motivated by the ability of clay nanoparticles to self-organise into gels, potentially allowing stem-cells to be delivered and retained at an injury site via injection and gel-formation in situ. Early on Jon encountered significant problems recovering biological information from clay-gel encapsulated cells due to the tendency of biological molecules to stick to clay particles. This ‘sticky’ problem presented, however, a unique opportunity to control the stem cell environment through the ability of clay particles to hold biological signals in space and over time. Jon has since developed a range of assays to confirm the ability of clay-associated molecules to direct stem cell behaviour. The exciting results from these early studies and the fruitful interactions that have followed constitute the background to much of his current work. Jon has worked as a postdoctoral research fellow within the field of stem cell biology and published in journals such as Stem Cells, Advanced Materials, Bone and Biomaterials. He has also worked closely with clinicians engaged in translational stem cell research and in 2010 was awarded The Engineer Award for a collaboration with industry and clinicians developing an intra-operative bone marrow stem cell concentration method.

研究领域

on leads a team exploring how gels formed from clay nanoparticles could be harnessed to create injectable tissues that would develop from stem cells in situ and eliminate, in many situations, the need for surgery Injectable stem cell microenvironments Essential to harnessing the potential of stem-cells to regenerate tissue is the ability to carefully control their local biological environment. The open structures of conventional scaffolds or gels means their ability to control the biological molecules present in the local environment is limited. The ability of clay nanoparticles to bind such molecules presents a unique opportunity to create local environments at a site of injury or disease that could stimulate and control stem cell driven repair. That molecules stick to clay has been known by scientists since the 1960s. Doctors observed that absorption into the blood stream of certain drugs was severely reduced when patients were also receiving clay-based antacid or anti-diarrheal treatments. This curious phenomenon was realized to be due to binding of the drugs by clay particles. This interaction is now routinely harnessed in the design of tablets to carefully control the release and action of a drug. Combined with the ability of certain clay nanoparticles to self- organize into gels, Jon’s group is seeking to use this property of clay to create injectable micro-environments that could stimulate stem cells to regenerate damaged tissues such as bone and skin. Basic and translational stem cell biology Working closely with skeletal stem cell experts Professor Richard Oreffo, University of Southampton, and Professor Moustapha Kassem, University of Southern Denmark, Jon is developing this approach as a means to gain new insights into the biological signalling underlying stem cell behavior. They hope eventually to be able to use clay gels to provide stem cells with these signals to stimulate bone regeneration Developing new materials As wells as forming gels clay particles can also interact with large structural molecules (polymers) that are frequently used in the development of materials (or 'scaffolds'), designed to host stem cells. These interactions can greatly improve the strength of such structures and could be applied to preserve their stability at the site of injury until regeneration is complete. Working with leading polymer chemists Jöns Hilborn, University of Uppsala and Kevin Shakescheff, University of Nottingham, Jon is exploring ways to apply clay nanoparticles to enhance the mechanical and biological properties of established biomedical materials

近期论文

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A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis. - Hulsart-Billstrom, G., Dawson, J.I., Hofmann, S., Müller, R., Stoddart, M.J., Alini, M., Redl, H., El Haj, A., Brown, R., Salih, V., Hilborn, J., Larsson, S. and Oreffo, R.O.C. Published:2016Publication:European Cells & MaterialsVolume:31Page Range:312-322PMID:27215739 Bone induction at physiological doses of BMP through localization by clay nanoparticle gels - Gibbs, D.M.R., Black, C.R.M., Hulsart-Billstrom, G., Shi, P., Scarpa, E., Oreffo, R.O.C. and Dawson, J.I. Published:2016Publication:BiomaterialsVolume:99Page Range:16-23doi:10.1016/j.biomaterials.2016.05.010PMID:27209259 A tissue engineering strategy for the treatment of avascular necrosis of the femoral head - Aarvold, A., Smith, John, Tayton, Edward R, Jones, A.M.H., Dawson, Jonathan I., Lanham, S.A., Briscoe, Adam, Dunlop, Douglas G. and Oreffo, Richard O.C. Published:2013Publication:The SurgeonVolume:11, (6)Page Range:319-325doi:10.1016/j.surge.2013.02.008PMID:23540814 Assessing the potential of colony morphology for dissecting the CFU-F population from human bone marrow stromal cells - Gothard, D., Dawson, J.I. and Oreffo, R.O.C. Published:2013Publication:Cell and Tissue Researchdoi:10.1007/s00441-013-1564-3PMID:23397425