Collins, Jane - University of Southampton

个人简介

Jane Collins' research interests centre on epithelial molecular cell biology with a strong emphasis in the study of cell-cell adhesion mechanisms and cellular differentiation. Her main research focus is the impact of inflammation on epithelial barrier properties and the regulation of innate immunity at mucosal surfaces, including airway, kidney and intestine. She leads a group based in the School of Medicine which comprises scientists, clinicians and postgraduate students, which is widely interactive with academics and clinicians within the School, the NHS and cross-faculty in the University. Jane Collins was appointed Senior Lecturer in the School of Medicine, University of Southampton in 2007. She began her postdoctoral studies with Professor David Garrod (University of Manchester) cloning and sequencing cDNA for desmocollins, calcium-dependent adhesive glycoproteins of desmosomes. She went on to study the transcriptional regulation of the desmocollin genes in the early mammalian embryo with Professor Tom Fleming at the University of Southampton in 1992 and Dr Roger Buxton at the National Institute for Medical Research at Mill Hill in 1996, before taking up a lectureship in the School of Medicine, University of Southampton in 1999. In addition to research, Jane is an actively involved in teaching undergraduates and postgraduates and has a major role in coordinating the 4 year integrated PhD in Biomedical Sciences in the School of Medicine.

研究领域

The theme of Dr Collins’ research is mechanisms used by epithelia to maintain the tissue barriers that interface with the external environment, thus protecting the organism from inappropriate exposure to injurious antigens and the regulation of epithelial cytokine responses that impact on innate immunity. Integral to generating a stable epithelial boundary are cell to cell adherens and tight junctions between the cells. These intercellular adhesion sites selectively regulate tissue permeability, enabling the vectorial transepithelial movement of ions, sugars and proteins. In addition, they sequester signalling proteins, growth factor receptors and transcription factors reflecting their critical role in determining the phenotypic responses of cells in sites of tissue damage and inflammation. Since coming to the University of Southampton, Dr Collins has applied her knowledge of epithelia to study the effect of inflammation with the aim of discovering strategies for preventing the deleterious and chronic effects of inflammation, with its negative implications for tissue homeostasis. The recent emphasis of her studies concerns the innate immune response by epithelia in the gut, kidney and airway and how these might be modified therapeutically in chronic diseases including asthma, kidney fibrosis and inflammatory bowel disease. Current projects include the role of TNFα, IL-6 and specific miRNAs in the coordination of epithelial barrier and inflammatory cytokine release. Dr Collins collaborates widely within the University and externally with other universities and pharmaceutical company scientists.

近期论文

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Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA - Blume, Cornelia, Reale, Riccardo, Held, Marie, Loxham, Matthew, Millar, Tim, Collins, Jane, Swindle, Emily, Morgan, Hywel and Davies, Donna Published:2016Publication:Immunity, Inflammation and DiseasePage Range:1-34 Temporal monitoring of differentiated human airway epithelial cells using microfluidics - Blume, Cornelia, Reale, Riccardo, Held, Marie, Millar, Timothy M., Collins, Jane E., Davies, Donna E., Morgan, Hywel and Swindle, Emily J. Published:2015Publication:PLoS ONEVolume:10, (10)Page Range:1-13doi:10.1371/journal.pone.0139872PMID:26436734 Wild meat: a shared resource amongst people and predators - Foster, R. J., Harmsen, B. J., Macdonald, D. W., Collins, J., Urbina, Y., Garcia, R. and Doncaster, C. P. Published:2014Publication:OryxPage Range:1-13doi:10.1017/S003060531400060X