Cleary, David - University of Southampton

个人简介

Dr Cleary is a post-doctoral research fellow and early career researcher in microbial genomics in the Infectious Disease Epidemiology group. His research focuses on the application of genomics technology to understand the prevalence, spread and pathogenicity of infectious disease. His expertise includes characterising polymicrobial carriage in both respiratory disease and healthy cohorts using 16S rRNA and metagenomic approaches. Dr Cleary received his BSc (HONS) in Medical Microbiology from the University of Surrey in 2002. He went on to complete his PhD with the University of Warwick in 2013 whilst employed as a microbiologist at the Defence Science and Technology Laboratories, Porton Down. His PhD research centered on the impacts of relative abundance, gene transfer and persistence of target DNA in relation to the detection of microbial taxa in complex communities. Prior to this appointment, he was a Senior Scientist and Technical Lead for Genomics within the Biological Sciences Group at the Defence Science Technology Laboratory, Porton Down. He led a number of research programmes including those concerned with the environmental and ecological interactions of pathogenic organisms, quasispecies dynamics of RNA viruses, detection of pathogens within bioaerosols, aerobiological responses of select agents and the design and development of analytical techniques for pathogen detection.

研究领域

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The emphasis of Dr Cleary’s research is the application of genomics (DNA sequencing) and bioinformatic analyses to investigate the drivers of bacterial pathogen evolution within healthy human populations compared to those with underlying chronic illnesses. Central to this area of research is our increased understanding of the intricate and balanced relationship between microorganisms within our bodies (our microbiomes) and the results of dysbiosis. This may arise as a result of environmental pressures, clinical interventions or the changing epidemiology of carriage, infection, or indeed simply colonisation with bacterial pathogens. Dr Cleary’s research is predominantly focused on investigating the epidemiology of bacterial infectious diseases of the respiratory tract. This includes determining the changing epidemiology of potentially pathogenic commensals such as non-typeable Haemophilus influenzae (NTHi), Streptococcus pneumoniae, Staphylococcus aureus and Moraxella catarrhalis.