Clark, Tristan - University of Southampton

个人简介

Dr Clark qualified as a doctor from Southampton University in 1998 and undertook his early clinical training in Poole, Southampton , Portsmouth and Bristol. He subsequently spent time working abroad, firstly in Sudan running TB and Visceral Leishmaniasis programmes, and then in Darwin, Northern Australia doing clinical infectious diseases. He completed his Specialist registrar training in Infectious diseases and general internal medicine in Leicester where he gained a wealth of experience in the clinical management of TB (including MDRTB), HIV and viral hepatitis. Whilst training in Leicester Dr Clark developed research interests in Influenza and other respiratory viruses and completed an MD thesis. He ran several pandemic influenza vaccine trials including avian H5 and swine origin H1 influenza. Other themes from his research have included; the utility of rapid diagnostic tests for influenza and pneumococcus, the clinical application of biomarkers (Procalcitonin and CRP) in acute respiratory illness, the burden of respiratory virus infection in hospitalised adults and the molecular epidemiology of human rhinovirus.

研究领域

Pandemic Influenza vaccines Dr Clark was part of a team that evaluated the safety and immunogenicity of pandemic influenza vaccines against swine origin H1N1, the results of which have been published in high impact international journals. He has also evaluated a prime-boost vaccination strategy against avian H5 influenza. Potential ongoing projects include vaccine evaluation against the newly emerging H7N9 influenza virus in China, which has pandemic potential. Respiratory viruses in hospitalised adults Dr Clark is currently running clinical trials at UHS examining the use of point-of-care diagnostics for respiratory virus infection in hospitalised adults. Dr Clark has examined the role of respiratory viruses in adults hospitalised with acute respiratory illness and found a high burden of viruses, particularly Human Rhinovirus. Potential ongoing projects include prospective studies in hospitalised adults using universal screening. Rapid diagnostic tests and biomarkers Dr Clark has explored the role of biomarkers such as CRP and Procalcitonin and rapid diagnostic tests for influenza and pneumococcus in improving the clinical management of hospitalised adults with acute respiratory disease. Potential ongoing projects include evaluating the use of novel rapid molecular diagnostic tests for influenza.

近期论文

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Viral load is strongly associated with length of stay in adults hospitalised with viral acute respiratory illness - Clark, Tristan, Sean, Ewings, Marie-jo, Medina, Sally, Batham, Martin, Curran, Surendra , Parmar and Karl , Nicholson Published:2016Publication:Journal of Infectiondoi:10.1016/j.jinf.2016.09.001.PMID:27615557 Severe enterovirus infections in hospitalized children in the South of England - clinical phenotypes and causative genotypes - De Graaf, H., Pelosi, E., Cooper, A., Pappachan, J., Sykes, K., MacIntosh, I., Gbesemete, D., Clark, T.W., Patel, S.V., Faust, S.N. and Tebruegge, M. Published:2016Publication:The Pediatric Infectious Disease JournalPage Range:1-24doi:10.1097/INF.0000000000001093PMID:26882165 Point-of-care testing for respiratory viruses in adults: The current landscape and future potential - Brendish, Nathan J., Schiff, Hannah F. and Clark, Tristan W. Published:2015Publication:Journal of Infectiondoi:10.1016/j.jinf.2015.07.008PMID:26215335 Are C-reactive protein levels associated with bacteria in COPD exacerbations? - Clark, Tristan W. Published:2015Publication:European Respiratory JournalVolume:45, (5)Page Range:1515-1516doi:10.1183/09031936.00020015PMID:25931496