Christodoulides, Myron - University of Southampton

个人简介

Myron Christodoulides is a graduate in microbiology from University College London and the University of Glasgow and a specialist in bacteriology. After postdoctoral fellowships with the Government of Canada and at the University of Newcastle, Myron began a long association with the Neisseria Research Group at the University of Southampton. His basic research is in bacterial pathogenesis, with a primary emphasis on the cellular and molecular basis of meningitis. There is also a strong translational element to his research, which began from his PhD studies on the development of novel acellular pertussis (whooping cough) vaccines. Current vaccine research is goal-orientated towards identification and preclinical evaluation of Neisseria meningitidis antigens as potential vaccine candidates.

研究领域

1. Meningococcal and Gonococcal Vaccines: developing vaccines for Neisseria meningitidis (meningococcus) meningitis and Neisseria gonorrhoeae STDs has been a core area of my research and has depended a great deal on a basic understanding of bacterial antigen/virulence factor interactions with the human host. These projects involve investigating proteins contributing to inducing protective immunity in humans following bacterial infection and colonisation; structural protein studies; their role in human host cell interactions; immune-proteomics studies on responses to human meningococcal vaccines; development of DNA-based vaccines and nanoparticle delivery systems. One meningococcal protein –the macrophage infectivity potentiator (MIP) protein -identified has now been licensed to a major pharmaceutical company. A patent application for another even more promising protein, the Adhesin Complex Protein (ACP) has been filed. A recent award from the MRC supports continued vaccine work on this protein. These antigens also have potential for gonococcal vaccines, a neglected area of research that needs re-energizing in light of the increased resistance of gonococci to antibiotics. 2. Pathogenesis of Neisseria infections. a) Neisseria gonorrhoeae (gonococcus) salpingitis: a long-standing collaboration with colleagues in Chile (Dr L Velasquez, Dr. Rodas), studying the molecular and cellular basis of gonococcal infection of the human female reproductive tract. b) Neisseria meningitidis mechanisms of virulence and host cell responses. 3. Pathogenesis of other bacterial infections. a) Streptococcus agalactiae neonatal meningitis. b) Streptococcus pneumoniae infection: studying the molecular basis of pneumococcal empyema. c) In collaboration with Dr. Parwez Hossain, University of Southampton, we are investigating the molecular and cellular basis of microbial keratitis, focusing on pathogen interactions with the cornea. These include diverse organisms as Pseudomonas aeruginosa, S. pneumonia, N.gonorrhoeae and Staphylococcus aureus. Collaboration with Dr. Schubert-Unkmeir, Wurzburg, Germany, on investigating bacterial mechanisms of invasion. d) Streptococcus suis meningitis: collaboration with Professor Gottschalk, University of Montreal, Canada, fulfilling the ‘One Health’ agenda of tackling human and animal disease. e) Collaboration with Dr Arden-Jones (Dermatology) to study microbial skin infection (Colworth iCASE, BBSRC-Unilever award). f) Fusobacterium spp. interactions with human cells, in collaboration with Dr. Darryl. Hill, University of Bristol.

近期论文

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Modified profile of matrix metalloproteinase-2 and -9 production by human Fallopian tube epithelial cells following infection in vitro with Neisseria gonorrhoeae - Rodas, Paula, Perez, Doris, Jauffret, Claudia, Gonzalez, Yaquelin, Carreno, Carolina, Tapia, Cecilia, Osorio, Eduardo, Velasquez, Luis and Christodoulides, Myron Published:2016Publication:The Journal of Infectious DiseasesPage Range:1-14doi:10.1093/infdis/jiw568PMID:27932616 Viral inhibition of bacterial phagocytosis by human macrophages: redundant role of CD36 - Cooper, Grace E, Pounce, Zoe C, Wallington, Joshua, Bastidas Legarda, Leidy Y., Nicholas, Benjamin, Chidomere, Chiamaka, Robinson, Emily C., Martin, Kirstin, Tocheva, Anna S., Christodoulides, Myron, Djukanovic, Ratko, Wilkinson, Thomas M.A. and Staples, Karl J Published:2016Publication:PLoS ONEVolume:11, (10)Page Range:1-15doi:10.1371/journal.pone.0163889PMID:27701435 Vaccines for piscirickettsiosis (salmonid rickettsial septicaemia, SRS): the Chile perspective. - Maisey , Kevin, Montero, Ruth and Christodoulides, Myron Published:2016Publication:Expert Review of VaccinesPage Range:1-14doi:10.1080/14760584.2017.1244483PMID:27690686 Vaccine potential and diversity of the putative cell binding factor (CBF, NMB0345/NEIS1825) protein of Neisseria meningitidis - Humbert, Maria, Hung, Miao-Chiu, Phillips, Renee, Akoto, Charlene, Hill, Alison, Tan, Wei-Ming, Heckels, John and Christodoulides, Myron Published:2016Publication:PLoS ONEVolume:11, (8)Page Range:e0160403doi:10.1371/journal.pone.0160403.PMID:27505005 The NarE protein of Neisseria gonorrhoeae catalyzes ADP-ribosylation of several ADP-ribose acceptors despite an N-terminus deletion - Rodas, Paula I., Alamos-Musre, A. Said, Álvarez, Francisca, Escobar, Alejandro, Tapia, Cecilia V., Osorio, Eduardo, Otero, Carolina, Calderón, Iván L., Fuentes, Juan A., Gil, Fernando, Paredes-Sabja, Daniel and Christodoulides, Myron Published:2016Publication:FEMS Microbiology LettersPage Range:1-31doi:10.1093/femsle/fnw181PMID:27465490