Calder, Philip - University of Southampton

个人简介

I have broad research interests in nutritional modulation of immunity, inflammation and cardiometabolic disease risk. Much of my work has been devoted to exploring the metabolism and functionality of fatty acids with an emphasis on the roles of omega-3 fatty acids. I have over 500 scientific publications and I am listed by Thomson Reuters as a Highly Cited Researcher. I have been awarded the Sir David Cuthbertson Medal by the Nutrition Society (1995), the Belgian Danone Institute Chair (2004), the Nutricia International Award (2007), the ESPEN Cuthbertson Lecture (2008), the New Zealand Nutrition Society’s Muriel Bell Award (2009), the Louisiana State University Chancellor’s Award in Neuroscience and Medicine (2011), the German Society for Fat Science Normann Medal (2012), the American Oil Chemists’ Society Ralph Holman Lifetime Achievement Award (2015), the British Association for Parenteral and Enteral Nutrition Pennington Lecture (2015), the British Nutrition Foundation prize (2015) and the Danone International Prize in Nutrition (2016). I have served on many committees of professional societies and was for three years President of the International Society for the Study of Fatty Acids and Lipids (2009-2012). I am currently Chair of the Scientific Committee of the European Society for Clinical Nutrition and Metabolism (ESPEN) and President of the Nutrition Society. I was Editor-in-Chief of the British Journal of Nutrition from 2006 to 2013 and I am currently an Associate Editor of Clinical Science, of Journal of Nutrition, of Clinical Nutrition, of Lipids, and of Nutrition Research. I am a member of the several other Editorial Boards of journals in the nutrition, clinical science and lipidology fields. I currently serve as scientific co-chair of the ILSI Europe Task Force on Nutrition immunity and inflammation and on the ILSI Europe Scientific Advisory Committee. I am a Fellow of the Royal Society for Biology and of the Association for Nutrition.

研究领域

Professor Calder is interested in the interaction between nutrition and immune function especially as it relates to human health. The main focus of his research aims to identify the influence of dietary fatty acids on the immune and inflammatory systems and to understand the mechanisms of action of specific fatty acids. A combination of in vitro, ex vivo and in vivo approaches is used to study the functional responses of neutrophils, monocytes/macrophages and lymphocytes. A range of anti-inflammatory and immunomodulatory effects of the n-3 family of polyunsaturated fatty acids, particularly those found in fish oils, have been identified. It has been ascertained that these fatty acids work in part by antagonising the production and actions of arachidonic acid-derived eicosanoids and in part by eicosanoid-independent mechanisms. The findings of this research aid our knowledge of the health benefits of naturally-occurring fatty acids and provide information to underpin the design of nutritionally-based therapies for use in situations where components of the immune and inflammatory systems are under or over active.

近期论文

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Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids - de Castro, G. and Calder, P. Published:2017Publication:Clinical NutritionPage Range:1-34 Systematic review on n-3 and n-6 PUFA intake in European countries in light of the current recommendations – focus on specific population groups - Sioen, I., van Lieshout, L., Eilander, A., Fleith, M., Lohner, S., Szommer, A., Petisca, C., Eussen, S., Forsyth, S., Calder, Philip, Campoy, C. and Mensink, R. Published:2017Publication:Annals of Nutrition and MetabolismPage Range:1-25 Influence of different intravenous lipid emulsions on fatty acid status and laboratory and clinical outcomes in adult patients receiving home parenteral nutrition: A systematic review. - Jones, C. and Calder, Philip Published:2016Publication:Clinical NutritionPage Range:1-26 Plasma levels of the n-3 polyunsaturated fatty acid eicosapentaenoic acid are associated with anti-TNF responsiveness in rheumatoid arthritis, and inhibit the etanercept driven rise in Th17 cell differentiation in vitro - Jeffery, L., Fisk, H.L., Calder, P.C., Filner, A., Raza, K., Buckley, C.D., McInnes, I., Taylor, P.C. and Fisher, B.A. Published:2016Publication:The Journal of RheumatologyPage Range:1-27