Burdge, Graham - University of Southampton

个人简介

Professor Burdge graduated in Cell and Immunobiology from the University College of Wales, Aberystwyth in 1985 and was awarded a PhD from the Department of Medical Oncology, University of Southampton in 1990. He joined the Department of Child Health, University of Southampton, in 1987 to study pulmonary surfactant biosynthesis. During this period he developed an interest in polyunsaturated fatty acid metabolism in pregnancy and fetal development. This included projects on the effect of ethanol exposure on the developing brain and the effect of fatty acids on neuroblastoma differentiation. He subsequently moved to the Institute of Human Nutrition, University of Southampton, where he carried out research on human polyunsaturated fatty acid metabolism. He was awarded a British Heart Foundation Intermediate Fellowship in 2006, and was appointed Lecturer in Human Nutrition (2007) and subsequently Reader/Associate Professor in Human Nutrition (2009). He was awarded a personal chair in nutritional biochemistry in 2015.

研究领域

In collaboration with Professor Karen Lillycrop, Professor Burdge was the first to show that poor maternal nutrition altered the physiology of the offspring via changes in the epigenetic regulation of specific genes. He has subsequently shown that nutrition throughout the life course can modify epigenetic processes. The focus of Professor Burdge’s current research is understanding the interaction between nutrition, in particular lipids, and the epigenome, and how this changes across the life course. The aim of his research is develop nutritional strategies acting via the epigenome to ameliorate non-communicable disease. His work is funded by the British Heart Foundation, the BBSRC, the European Commission and the Gerald Kerkut Charitable Trust, The National Health and Medical Research Council of Australia and The Research Council of Norway, and by industrial partners. He is a founding member of the EpiGen Global Research Consortium. He has been identified by Thomson Reuters in 2014 and 2015 to been amongst the top 1% most cited authors in his field (http://highlycited.com)

近期论文

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Metabolism and functional effects of plant-derived Omega-3 fatty acids in humans - Baker , E., Miles, Elizabeth, Burdge, Graham, Yaqoob, P. and Calder, Philip Published:2016Publication:Progress in Lipid ResearchVolume:64Page Range:30-56doi:10.1016/j.plipres.2016.07.002PMID:27496755 Lipid structure does not modify incorporation 1 of EPA and DHA into blood lipids in healthy adults: a randomised control trial - West, Annette, Burdge, Graham and Calder, Philip Published:2016Publication:British Journal Of NutritionVolume:116, (5)Page Range:788-797doi:10.1017/S0007114516002713PMID:27424661 Fatty acid profiles of great tit (Parus major) eggs differ between urban and rural habitats, but not between coniferous and deciduous forests - Toledo, Alejandra, Andersson, Martin N, Wang, Hong-Lei, Salmon, Pablo, Watson, Hannah, Burdge, Graham C. and Isaksson, Caroline Published:2016Publication:The Science of NaturePage Range:1-33 Association between perinatal methylation of the neuronal differentiation regular HES1 and later childhood neurocognitive function and behaviour - Lillycrop, Karen A., Costello, Paula M, Teh, Ai Ling, Murray, Robert J., Clarke-Harris, Rebecca, Barton, Sheila J., Garratt, Emma S., Ngo, Sherry, Sheppard, Alan M., Wong, Johnny, Dogra, Shaillay, Burdge, Graham C., Cooper, Cyrus, Inskip, Hazel M., Gale, Catharine R., Gluckman, Peter D., Harvey, Nicholas C., Chong, Yap-Seng, Yap, Fabian, Meaney, Michael J., Rifkin-Grabot, Anne, Holbrook, Joanna and Godfrey, Keith M. Published:2016Publication:International Journal of EpidemiologyPage Range:1-48