Buchan, Sarah - University of Southampton

个人简介

Dr Buchan completed her PhD at the University of Southampton in 2005 studying the optimization of vaccine design and delivery to maximize T-cell responses to cancer cells under Prof. F. K. Stevenson. The principles established by this research, and her subsequent work targeting the leukemia-associated antigen WT1, triggered the inception of several ongoing clinical trials in cancer patients, overseen by Prof C. Ottensmeier. In 2008 she moved to the group of Prof. Al-Shamkhani to study how members of the tumour necrosis factor superfamily modify the quality and quantity of T-cell activation. In 2009 she was awarded the Faculty Post-Doctoral Career Track Award enabling her to continue her research investigating the processes that regulate T-cell activity and function and how this information can be exploited for the eradication of cancer.

研究领域

Dr Buchan’s research interests revolve around the biology of T lymphocytes, a key cell type used by the immune system to combat infectious disesases and cancer. Her research seeks to understand how these cells can be activated to respond to tumour cells in vivo and how T-cell activity can be maintained in the face of suppressive mechanisms exploited by tumour cells.

近期论文

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Akt signaling is critical for memory CD8+ T cell development and tumor immune surveillance - Rogel, Anne, Willoughby, Jane E., Buchan, Sarah L., Leonard, Henry J., Thirdborough, Stephen M. and Al-Shamkhani, Aymen Published:2017Publication:Proceedings of the National Academy of SciencesPage Range:1-53 OX40- and CD27-mmediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence - Buchan, S., Manzo, T., Flutter, B., Rogel, A., Edwards, N., Zhang, L., Sivakumaran, S., Ghorashian, S., Carpenter, B., Bennett, C.L., Freeman, G.J., Sykes, M., Croft, M., Al-Shamkhani, A. and Chakraverty, R. Published:2014Publication:The Journal of ImmunologyVolume:194, (1)Page Range:125-133doi:10.4049/jimmunol.1401644PMID:25404365 Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization - Willoughby, J.E., Kerr, J.P., Rogel, A., Taraban, V.Y., Buchan, S.L., Johnson, P.W. and Al-Shamkhani, A. Published:2014Publication:The Journal of ImmunologyVolume:193, (1)Page Range:244-251doi:10.4049/jimmunol.1301217PMID:24860188 CD27 costimulation contributes substantially to the expansion of functional memory CD8+ T cells after peptide immunization - Taraban, V.Y., Rowley, T.F., Kerr , J.P., Willoughby, Jane E., Johnson, Peter W.M., Al-Shamkhani, A. and Buchan, S.L. Published:2013Publication:European Journal of ImmunologyVolume:n/aPage Range:1-29doi:10.1002/eji.201343579PMID:24002868