Blaydes, Jeremy - University of Southampton

个人简介

Dr Jeremy Blaydes is Reader in Cancer Cell Biology within Medicine at the University of Southampton. Dr. Blaydes was appointed as Lecturer at the University of Southampton in 2000, and Reader in Cancer Cell Biology in 2007. His research in based in the Somers Cancer Research Building on the Southampton General Hospital Campus Dr. Blaydes’ research focuses on transcriptional responses to stress signalling pathways, and their roles in the causes and treatment of cancer. Qualifications BSc Biochemistry, University of Bath. 1990 PhD Cancer Cell Biology, University of Wales, College of Medicine (UWCM), 1994

研究领域

Transcriptional responses to pathways: roles in the causes and treatment of cancer Intra-cellular stress-response pathways are activated in response to potentially deleterious conditions in the cell’s environment. In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. In complex multi-cellular organisms such as man, they are critical in maintaining the normal function of each organ in the body, and the survival of the organism as a whole. Stress-response pathways play a key role in the patho-physiology and treatment of many diseases, including cancer. At almost every stage of the development of a tumour, cells are exposed to some form of stress. Examples include exposure to toxic compounds or radiation, loss of contact with other cells or the extra-cellular matrix, lack of oxygen (hypoxia), acidic pH, the activation of oncogenes, induction of cellular senescence, oxidative damage or depletion of essential metabolites. In some circumstances, the activation of a stress-response pathway will actually help the tumour cell to survive and proliferate. In other situations the response is cell cycle arrest or programmed cell death (apoptosis), providing a barrier to further tumour development that the tumour may ultimately circumvent through the acquisition of a mutation in one of the genes within the stress-response pathway. The p53 tumour suppressor protein is a key component of one such stress-response pathway, and virtually all cancers loose functionality of the p53-stress response pathway. Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways. Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. We have a long-standing interest in the p53 protein, a stress-activated transcriptional activator. We have also developed interests in other pathways which regulate gene transcription and cancer cell proliferation in response to stress and changes in cell metabolism. We aim to determine the role of these pathways in the development of cancer, and establish the potential for targeting components of the pathways for cancer therapy. Our group is based in the purpose-built Somers Cancer Research Building. Modern, well equipped laboratories provide us with an excellent research environment, and the opportunity to interact with researchers working on related areas of cancer biology.

近期论文

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Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action - Smith, Lindsay D., Leme De Calais, Flavia, Raponi, Michela, Mellone, Massimiliano, Buratti, Emanuele, Blaydes, Jeremy P., Baralle, Diana and , Published:2016Publication:International Journal of CancerPage Range:1-18doi:10.1002/ujc.30574PMID:27997688 The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ - Papadakis, E.S., Barker, C.R., Syed, H., Reeves, T., Schwaiger, S., Stuppner, H., Troppmair, J., Blaydes, J.P. and Cutress, R. Published:2015Publication:OncogenesisPage Range:1-30 Synthesis and evaluation of a (3R, 6S, 9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-transPro in poly-L-proline type II helix conformation - Aillard, Boris, Kilburn, Jeremy D., Blaydes, Jeremy P., Tizzard, Graham J., Findlow, I.Stuart C. , Werner, Jörn M. and Bloodworth, Sally Published:2015Publication:Organic & Biomolecular ChemistryVolume:13Page Range:4562-4569doi:10.1039/c5ob00180c Cancer associated fibroblasts predict for poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma - Underwood, Timothy J., Hayden, Annette L., Derouet, Mathieu, Garcia, Edwin, Noble, Fergus, White, Michael J., Thirdborough, Steve, Mead, Abbie, Clemons, Nicholas, Mellone, Massimiliano, Uzoho, Chudy, Primrose, John N, Blaydes, Jeremy P and Thomas, Gareth J Published:2015Publication:The Journal of PathologyVolume:235Page Range:466-477doi:10.1002/path.4467PMID:25345775