Ardern-Jones, Michael - University of Southampton

个人简介

Dr Michael Ardern-Jones is Associate Professor within Medicine at the University of Southampton. Mike Ardern-Jones undertook medical training at St Bartholomew's Medical College, University of London and subsequently carried out his DPhil studies at Christ Church, University of Oxford. He trained in cutaneous immunology at the Weatherall Institute of Molecular Medicine, University of Oxford via a Wellcome Research Training Fellowship. The aim of his group is to develop model systems for human inflammatory cutaneous disease which will develop the opportunity to dissect key molecular pathways and design new science based treatments. As a paradigm for such a system, atopic dermatitis is ideal and is where the main thrust of work is directed. He found an exciting novel link between the role of infection in modulating allergic responses in the skin, which suggests an important bridge between the innate immune control of adaptive immune responses and extending this work in more physiological model systems is a current principle aim. Funding for his research has come from: The Wellcome Trust, Biotechnology and Biological Sciences Research Council (BBSRC), British Skin Foundation, Psoriasis Association, Mason Medical Foundation, AAIR (Asthma, Allergy, Inflammation Research Charity), Health Protection Agency, Higher Education Innovation Funding (HEIF), Emblation Ltd., Unilever.

研究领域

Together with Dr Polak (Post Doctoral Research Scientist), Dr Ardern-Jones has developed a 3D in vitro model of the skin which can be used to further investigate cutaneous immunology without the need for human tissue samples. Skin research has a distinct advantage over other organ systems in that there is good access to skin biopsies if needed. Using the latest immunological tools (Fig1 novel MHC class II tetramers..) Dr Ardern-Jones aims to address key questions in cutaneous immunology. The group has 4 main areas of interest within the field: 1) The role of microbial regulation of immune responses in atopic dermatitis Infections are well recognised causes of flares in eczema. Using laboratory cultured Staphylococcus aureus, Dr Ardern-Jones is investigating how this bacteria can redirect the cutaneous immune response towards allergic responses. 2) The interaction between cutaneous DCs and adaptive immunity It has long been established that certain cytokine profiles correspond with allergic reactions, yet why some individuals and not others should programme their immune responses in this way is not well understood. Testing cells outside of the tissue microenvironment fails to reproduce the signals that coordinate an individual immune response. Using 3D models of the skin, Dr Ardern-Jones’ group can test the molecular pathways involved in this immune programming. 3) Development of novel in vitro diagnostic tests for drug hypersensitivity Allergic reactions to drugs are mediated by immune responses in the blood and frequently manifest as rashes on the skin. Although many are mild, some can be fatal. To date we have no reliable methods of identification of the culprit medication and therefore clinical management of these cases is often based on bets guess and is less than satisfactory. Using his experience in working with immunological tests for other projects, Dr Ardern-Jones’ group is recognised as the leading group in the UK working on assay optimisation for clinical use. 4) Mathematical modelling of the regulation of Th polarisation Complexity in biological systems has driven a reductionist approach, whereby favourite molecules or pathways are examined in depth. New technologies such as microarray analysis of encoded RNA, allows researchers to study complexity in a non-hypothesis driven way. As part of Dr Ardern-Jones’ group, Dr Polak is using microarray analysis and novel bioinformatics systems to model the whole cellular processing that regulates a dendritic cell to at one time choose to induce immunity and at other times allergy.

近期论文

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UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016 - Creamer, D., Walsh, S.A., Dziewulski, P., Exton, L.S., Lee, H.Y., Dart, J.K.G., Setterfield, J., Bunker, C.B., Ardern-Jones, M.R., Watson, K.M.T., Wong, G.A.E., Philippidou, M., Vercueil, A., Martin, R.V., Williams, G., Shah, M., Brown, D., Williams, P., Mohd Mustapa, M.F. and Smith, C.H. Published:2016Publication:Journal of Plastic, Reconstructive & Aesthetic SurgeryVolume:69, (6)Page Range:e119-e153doi:10.1016/j.bjps.2016.01.034PMID:27287213 Staphylococcus aureus and chronic folliculocentric pustuloses of the scalp - cause or association? - Lee, A.H.Y., Cho, S.Y., Yam, T.S., Harris, K. and Ardern-Jones, M R Published:2016Publication:British Journal of DermatologyVolume:175, (2)Page Range:410-413doi:10.1111/bjd.14518PMID:26949158 In vitro rapid diagnostic tests for severe drug hypersensitivity reactions in children - Haw, Wei Yann, Polak, Marta, Mcguire, Carolann, Erlewyn-Lajeunesse, Michel and Ardern-Jones, Michael Published:2016Publication:Annals of Allergy, Asthma & ImmunologyVolume:117, (1)Page Range:61-66doi:10.1016/j.anai.2016.04.017PMID:27221062 Retrospective case note review of chronic spontaneous urticaria outcomes and adverse effects in patients treated with omalizumab or ciclosporin in UK secondary care - Savic, Sinisa, Marsland, Alexander, McKay, David, Ardern-Jones, Michael R., Leslie, Tabi, Somenzi, Olivier, Baldock, Laura and Grattan, Clive Published:2015Publication:Allergy Asthma & Clinical ImmunologyVolume:11, (21)Page Range:1-11doi:10.1186/s13223-015-0088-7PMID:26195984