Arden, Nigel - University of Southampton

个人简介

Professor Nigel Arden is Professor in Rheumatic Diseases within Medicine at the University of Southampton. Professor Arden trained at St Thomas’s Hospital, London, where he also completed four years of research into the genetics of osteoporosis. During this time, he gained an MSc in Epidemiology and an MD. He moved to the South Coast in 1996 and in 1998 spent six months as Visiting Assistant Professor in Epidemiology at the University of San Francisco. In 2000 he commenced his post as Senior Lecturer in Rheumatology and Honorary Consultant Rheumatologist at Southampton University NHS Trust. In 2008, he became a Professor in Rheumatic Diseases at Southampton University and also commenced an appointment with the University of Oxford to develop a joint research department between the two universities of Oxford and Southampton. He is based jointly at the Medical Research Council Epidemiology Resource Centre, Southampton and the Botnar Research Centre, Oxford; where he continues his research into osteoarthritis and osteoporosis. His clinical interests include all aspects of the rheumatic diseases; however he has special interests in osteoporosis, with particular emphasis on bone disease in patients with cystic fibrosis and inflammatory bowel disease. He additionally has a strong interest in the management of patients with osteoarthritis.

研究领域

Research interests focus on the epidemiology of osteoarthritis and osteoporosis. Based in the Botnar Research Centre with additional sessions at the MRC Lifecourse Epidemiology Unit at the University of Southampton. The programme has several major strands: (a) the intrauterine and genetic origins of osteoarthritis, osteoporosis and vitamin D metabolism; (b) the descriptive epidemiology of osteoarthritis and lower limb arthroplasty and (c) clinical trials in the management of common musculoskeletal conditions. Expanding research programmes are based around: (a) the complex genetic and environmental influences on osteoarthritis and more importantly their interaction (in collaboration with UCSF and the University of Oxford): (b) the epidemiology of knee and hip osteoarthritis; (c) the epidemiology and survival of total joint replacements in osteoarthritis: (d) the role of bone in the pathogenesis of osteoarthritis; (e) translational research in the form of a number of clinical trials in osteoarthritis. Further plans to clarify the risk factors for the incidence and progression of osteoarthritis, both radiographic and symptomatic, using a collection of large cohort studies. This work is funded by a large NIHR Biomedical Research Unit grant. A rapidly developing area of research is the epidemiology of joint arthroplasty. An NIHR Programme grant has been awarded aiming to accurately define the predictors of a successful arthroplasty and its cost effectiveness. It will also produce an accurate and comprehensive risk prediction model for the success of joint arthroplasty. The programme exploring the association between bone and osteoarthritis has two specific components: a) the effects of general bone size and density and, b) the effects of sub-chondral bone. We have shown that the association between systemic bone density and osteoarthritis is mainly driven by bone size and new data suggest the importance of bone shape. Further work in our existing cohorts using computerised tomography and conventional radiographs will further explore this important area of research. We will explore the role of sub-chondral bone using MRI and DXA in the VIDEO study, a large randomised trial of vitamin D in patients with OA. Its effect on the success of joint arthroplasty will be explored in the Oxford arthroplasty cohorts. A number of randomised controlled trials in patients with osteoarthritis have been completed. The current largest study is a three-year trial of the vitamin D supplementation in patients with knee osteoarthritis. As well as determining the role of vitamin D, this study will provide insight into the important mechanisms involved in determining disease progression including: the calcium / vitamin D axis; muscle function; bone mineral density and genetic factors.

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Do foot & ankle assessments assist the explanation of one year knee arthroplasty outcomes? - Gates, Lucy, Bowen, Catherine, Sanchez-Santos, M.T., Delmestri, A. and Arden, Nigel Published:2016Publication:Osteoarthritis and Cartilagedoi:10.1016/j.joca.2016.12.022 Determinants of the maternal 25-hydroxyvitamin D response to vitamin D supplementation during pregnancy - Moon, R.J., Harvey, N.C., Cooper, C., D'angelo, S., Crozier, S.R., Inskip, H.M., Schoenmakers, I., Prentice, A., Arden, N.K., Bishop, N.J., Carr, A., Dennison, E.M., Eastell, R., Fraser, R., Gandhi, S.V., Godfrey, K.M., Kennedy, S., Zulf Mughal, M., Papageorghiou, A.T., Reid, D.M., Robinson, S.M and Javaid, M.K. Published:2016Publication:Journal of Clinical Endocrinology & MetabolismPage Range:1-9doi:10.1210/jc.2016-2869PMID:27788053 Quantifying effect of age on the risk of revision following hip and knee replacement using life-time risk estimates: an analysis of 117,438 total joint replacements from the UK Clinical Practice Research Datalink - Bayliss, L.E., Culliford, D., Monk, A.P., Glyn-Jones, S., Prieto-Alhambra, D., Judge, A., Cooper, C., Carr, A.J., Arden, N., Beard, D. and Price, A.J. Published:2016Publication:The LancetPage Range:1-31 Cost-effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: a population based study - Leal, J., Gray, A.M., Hawley, S., Priero-Alhambra, D., Delmestri, A., Arden, N.K., Cooper, C., Javaid, M.K. and Judge, A. Published:2016Publication:Journal of Bone and Mineral ResearchPage Range:1-27doi:10.1002/jbmr.2995 PMID:27632945