Al-Shamkhani, Aymen - University of Southampton

个人简介

Professor Aymen Al-Shamkhani is Professor in Immunology within Medicine at the University of Southampton. Professor Al-Shamkhani was appointed to a personal Chair in 2007 after joining the University of Southampton in 1998 as Lecture and then Reader in Immunology. He obtained his BSc (Biochemistry) and PhD from Keele University. He then took up postdoctoral work in molecular and cellular immunology in the Sir William Dunn School of Pathology and the Department of Biochemistry at the University of Oxford. Professor Al-Shamkhani’s current research is focussed on providing a better understanding of the signals and molecules that regulate T cell activation and responses. His work on the costimulatory receptor CD27 led to the clinical development of anti-CD27 monoclonal antibodies as potential agents for promoting anti-tumour immunity. He has received external grant funding form a number of organisations including Cancer Research UK, Leukaemia & Lymphoma Research, The Wellcome Trust as well as the pharmaceutical industry.

研究领域

Professor Al-Shamkhani is interested in understanding how signals initiated by engagement of various cell surface receptors integrate during T cell activation in order to regulate effector T cell differentiation and the generation of memory cells. His research programme focuses on a group of structurally related proteins that belong to the tumour necrosis factor receptor superfamily. Engagement of these receptors has profound effects on the magnitude and quality of the T-cell response and current work in his laboratory is investigating the relative contribution of different members of this superfamily during immune responses and the molecular basis by which they mediate their effects. The long-term aim of Professor Al-Shamkhani’s research is to develop new approaches for cancer immunotherapy and the treatment of inflammatory diseases. For example, we are developing agonistic immumodulatory monoclonal antibodies and soluble recombinant TNF-like molecules that mimic the natural membrane-anchored proteins. Such agents will be used to boost cancer vaccines, or to promotes ongoing, but ineffectual anti-tumor T cell responses as well as overcoming suppression by regulatory T cells. We also have an active interest in developing agents that ameliorate inflammation but avoid blanket immunosuppression for the treatment of graft versus host disease.

近期论文

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Akt signaling is critical for memory CD8+ T cell development and tumor immune surveillance - Rogel, Anne, Willoughby, Jane E., Buchan, Sarah L., Leonard, Henry J., Thirdborough, Stephen M. and Al-Shamkhani, Aymen Published:2017Publication:Proceedings of the National Academy of SciencesPage Range:1-53 OX40 regulatory T cells in cutaneous squamous cell carcinoma suppress effector T cell responses and associate with metastatic potential - Lai, Chester, August, Suzannah, Albibas, Amel, Behar, Ramnik, Cho, Shin-Young, Polak, Marta, Theaker, Jeff, Macleod, Amanda S., French, Ruth, Glennie, Martin, Al-Shamkhani, Aymen and Healy, Eugene Published:2016Publication:Clinical Cancer ResearchPage Range:1-42doi:10.1158/1078-0432.CCR-15-2614PMID:27034329 Dysregulation of anti-viral function of CD8+T cells in the COPD lung: role of the PD1/PDL1 axis - McKendry, Richard T., Spalluto, C. Mirella, Burke, Hannah, Nicholas, Ben, Cellura, Doriana, Al-Shamkhani, Aymen, Staples, Karl J. and Wilkinson, Tom M.A. Published:2015Publication:American Journal of Respiratory and Critical Care MedicinePage Range:1-56doi:10.1164/rccm.201504-0782OCPMID:26517304 The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells - Richard, Arianne C., Tan, Cuiyan, Hawley, Eric T., Gomez-Rodriguez, Julio, Goswami, Ritobrata, Yang, Xiang-Ping, Cruz, Anthony C., Penumetcha, Pallavi, Hayes, Erika T., Pelletier, Martin, Gabay, Odile, Walsh, Matthew, Ferdinand, John R., Keane-Myers, Andrea, Choi, Yongwon, O'Shea, John J., Al-Shamkhani, Aymen, Kaplan, Mark H., Gery, Igal, Siegel, Richard M. and Meylan, Françoise Published:2015Publication:The Journal of ImmunologyVolume:194, (8)Page Range:3567-3582doi:10.4049/?jimmunol.1401220PMID:25786692