Abdollahi, Mohammad Reza - University of Southampton

个人简介

Dr Mohammad Reza Abdollahi is NIHR clinical lecturer in molecular pathology and specialty registrar in cellular pathology within Medicine at the University of Southampton. Mohammad Reza Abdollahi was appointed as NIHR clinical lecturer in pathology in 2014. He obtained his MD from Rafsanjan University of Medical Sciences and Health Services in Iran, and completed his PhD in genetics at the University of Southampton in 2004. He continued his research career with a postdoctoral position at the University of Bristol and a Fellowship in molecular genetics at the University of Leeds. He was appointed as a trainee in histopathology within the Wessex deanery in 2011.

研究领域

Research Background: MRA research interests lie in identification and analysis of mutations e.g. SNPs in relation to phenotypes at individual level and population scale. During his PhD, he worked on SNPs and haplotypes of the renin angiotensin pathway with emphasis on AGTR1 (angiotensin II, type 1 receptor) in relation to cardiovascular and metabolic traits. This led to identifying allele specific effect of an AGTR1 3’ UTR SNP on mRNA abundance. Subsequently, as a postdoc at the University of Bristol, he developed an integrated fluorescence multiplex assay for genotyping Apolipoproten E (APOE). This important development enabled scientists to rapidly genotype this gene in large scale epidemiological studies, without the risks of gel handling as in conventional genotyping techniques. During his fellowship at the Leeds Institute of Molecular Medicine, he used SNP chips to study patients with polymicrogyria from a consanguineous pedigree. He identified a splicing mutation in TUBA8, which deletes exon2 from the transcript. He continued this work with functional analyses to study the expression of the gene in developing brain.

近期论文

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Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals - Khan, Tauseef A., Shah, Tina, Prieto, David, Zhang, Weili, Price, Jackie, Fowkes, Gerald R., Cooper, Jackie, Talmud, Philippa J., Humphries, Steve E., Sundstrom, Johan, Hubacek, Jaroslav A., Ebrahim, Shah, Lawlor, Debbie A., Ben-Shlomo, Yoav, Abdollahi, Mohammad R., Slooter, Arjen J.C., Szolnoki, Zoltan, Sandhu, Manjinder, Wareham, Nicholas, Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne, Fillenbaum, Gerda, Heijmans, Bastiaan T., Katsuya, Tomohiro, Gromadzka, Grazyna, Singleton, Andrew, Ferrucci, Luigi, Hardy, John, Worrall, Bradford, Rich, Stephen S, Matarin, Mar, Whittaker, John, Gaunt, Tom R., Whincup, Peter, Morris, Richard, Deanfield, John, Donald, Ann, Davey Smith, George, Kivimaki, Mika, Kumari, Meena, Smeeth, Liam, Khaw, Kay-Tee, Nalls, Michael, Meschia, James, Sun, Kai, Hui, Rutai, Day, Ian, Hingorani, Aroon D. and Casas, Juan P. Published:2013Publication:International Journal of EpidemiologyVolume:42, (2)Page Range:475-492doi:10.1093/ije/dyt034PMID:23569189 Amplification ratio control system for copy number variation genotyping - Guthrie, Philip A.I., Gaunt, Tom R., Abdollahi, Mohammed R., Rodriguez, Santiago, Lawlor, Debbie A., Smith, George Davey and Day, Ian N.M. Published:2011Publication:Nucleic Acids ResearchVolume:39, (8)Page Range:e54doi:10.1093/nar/gkr046PMID:21300641 Use of genotype frequencies in medicated groups to investigate prescribing practice: APOE and statins as a proof of principle - Davies, Neil M., Windmeijer, Frank, Martin, Richard M., Abdollahi, Mohammad , Smith, George Davey, Lawlor, Debbie A., Ebrahim, Shah and Day, Ian N.M. Published:2011Publication:Clinical ChemistryVolume:57, (3)Page Range:502-510doi:10.1373/clinchem.2010.156356PMID:21228258 Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia - Abdollahi, Mohammad R., Morrison, Ewan, Sirey, Tamara, Molnar, Zoltan, Hayward, Bruce E., Carr, Ian M., Springell, Kelly, Woods, C. Geoff, Ahmed, Mushtaq, Hattingh, Louise, Corry, Peter, Pilz, Daniela T., Stoodley, Neil, Crow, Yanick, Taylor, Graham R., Bonthron, David T. and Sheridan, Eamonn Published:2009Publication:The American Journal of Human GeneticsVolume:85, (5)Page Range:737-744doi:10.1016/j.ajhg.2009.10.007PMID:19896110 Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI - Shugart, Yin Yao, Chen, Lina, Day, Ian N.M., Lewis, Sarah J., Timpson, Nicholas J., Yuan, Wei, Abdollahi, Mohammad Reza, Ring, Sue M., Ebrahim, Shah, Golding, Jean, Lawlor, Debbie A and Davey-Smith, George Published:2009Publication:European Journal of Human GeneticsVolume:17, (8)Page Range:1050-1055doi:10.1038/ejhg.2008.272PMID:19209189