Gerrard, Simon R - University of Southampton

个人简介

Dr Simon Gerrard studied Chemistry at the University of Bristol, which included a one-year placement at GlaxoSmithKline, and obtained his MSci (Hons) in 2003. Simon moved to Southampton in 2004 to study for his PhD with Prof. Tom Brown, working on DNA base-pair recognition within triple helices. In 2008, Simon started a Post-Doctoral position for Dr Eugen Stulz, working on DNA-templated chemical reactions, synthesis of DNA modifiers and porphyrin derivatives, and post-synthetic modification of oligonucleotides. In 2010, he moved back to work for Tom Brown as a Post-Doctoral Research Fellow. Here, he explored DNA-based nanotechnology, applying chemical and photochemical methodologies for development of DNA nanostructure synthesis and applications in biotechnology and genetic analysis. During this time, he also lectured on undergraduate courses and demonstrated workshops, tutorials and teaching labs. In March 2013, Simon moved in to undergraduate teaching full-time as an Organic Chemistry Teaching Fellow here in Southampton, then began a lectureship in July 2013, when he also became Deputy Chemistry Admissions Tutor. Simon is the Deputy Undergraduate Admissions Tutor (Chemistry) and Outreach Officer, and Organic Chemistry Teaching Fellow. He teaches undergraduates, co-organises and runs Chemistry student recruitment events, co-coordinates Outreach events for 10-17 year-olds, and gives careers talks in schools and colleges.

研究领域

My main interest is chemical modification of DNA, and using DNA as a construction material for formation of information-rich nanostructures with potential uses in a variety of biotechnological applications. Combining different chemistries (e.g. CuAAC and SPAAC ‘click’ chemistries, and photochemical crosslinking) with the programmability and structural capabilities of DNA provides a valuable tool for designer functional nucleic acids. I have also explored synthesis of modified cyanine dyes and fluorogenic dyes for oligonucleotide labelling, and genetic analysis applications, and investigated DNA-templated chemical synthesis.

近期论文

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Reversible ligation of programmed DNA-gold nanoparticle assemblies - Harimech, Pascal K., Gerrard, Simon R., El-Sagheer, Afaf H., Brown, Tom and Kanaras, Antonios G. Published:2015Publication:Journal of the American Chemical SocietyVolume:137, (29)Page Range:9242-9245doi:10.1021/jacs.5b05683 Triplex-mediated analysis of cytosine methylation at CpA sites in DNA - Johannsen, Marie W., Gerrard, Simon R., Melvin, Tracy and Brown, Tom Published:2014Publication:Chemical CommunicationsVolume:50, (5)Page Range:551-553doi:10.1039/C3CC45917A A new modular approach to nanoassembly: stable and addressable DNA nanoconstructs via orthogonal click chemistries - Gerrard, Simon R., Hardiman, Claire, Shelbourne, Montserrat, Nandhakumar, Iris, Nordén, Bengt and Brown, Tom Published:2012Publication:ACS NanoVolume:6, (10)Page Range:9221-9228doi:10.1021/nn3035759 Peptidomimetic bond formation by DNA-templated acyl transfer - McKee, Mireya L., Evans, Amanda C., Gerrard, Simon R., O'Reilly, Rachel K., Turberfield, Andrew J. and Stulz, Eugen Published:2011Publication:Organic & Biomolecular ChemistryVolume:9, (5)Page Range:1661-1666doi:10.1039/C0OB00753FPMID:21270981