个人简介

1996-1998 Postdoctoral Research Associate at Department of Chemistry, Princeton University (USA) 1998-1999 Researcher, ERATO, Japan Science and Technology Cooperation 1999-2000 Research Associate, RIKEN Genomic Sciences Center 2000- Assistant Professor, Department of Chemistry, The University of Tokyo

研究领域

Natural Products Chemistry/Analytical Chemistry

(1) Secondary Metabolite of Marine Invertebrates (2) Molecular Interaction of Membrane Associated Molecules (3) Mode of Action of Bioactive Compounds

近期论文

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Asanuma, M.; Fukuzawa, S.; Matsuda, T.; Hirota, H. The effect of SDS and anion exchange silica gel on MALDI-MS analysis of proteins. Rapid Commun. Mass Spectrom. 2009, 23, 1647-1653. Kinugawa, M.; Fukuzawa, S.; Tachibana, K. Skeletal protein protection: the mode of action of an anti-osteoporotic marine alkaloid, norzoanthamine. J. Bone Miner. Metab. 2009, 27, 303-314. Sasaki, T.; Kodama, K.; Suzuki, H.; Fukuzawa, S.; Tachibana, K. N-terminal Labeling of Proteins by the Pictet-Spengler Reaction. Bioorg. Med. Chem. Lett. 2008, 18, 4550-4553. Mimasu, S.; Sengoku, T.; Umehara, T.; Fukuzawa, S.; Yokoyama, S. Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 Å. Biochem. Biophys. Res. Commun. 2008, 366, 15-20. Sasaki, R.; Sasaki, H.; Fukuzawa, S.; Kikuchi, J.; Hirota, H.; Tachibana, K. Thermal analyses of phospholipid mixtures by differential scanning calorimetry and effect of doping with a bolaform amphiphile. Bull. Chem. Soc. Jpn. 2007, 80, 1208-1216. Kodama, K.; Fukuzawa, S.; Nakayama, H.; Kigawa, T.; Sakamoto, K.; Yabuki, T.; Matsuda, N.; Shirouzu, M.; Takio, K.; Yokoyama, S.; Tachibana, K. Site-specific Functionalization of Proteins by Organopalladium Reactions. ChemBioChem 2007, 8, 232-238. Kodama, K.; Fukuzawa, S.; Nakayama, H.; Kigawa, T.; Sakamoto, K.; Yabuki, T.; Matsuda, N.; Shirouzu, M.; Takio, K.; Tachibana, K.; Yokoyama, S. A New Protein Engineering Approach Combining Chemistry and Biology, Part I; Site-specific Incorporation of 4-iodo-L-phenylalanine in vitro Using Mis-acylated Suppressor tRNAPhe. ChemBioChem 2006, 7, 1577-1581. Fukuzawa, S.; Asanuma, M.; Tachibana, K.; Hirota, H. Combination of mixed self-assembled monolayer and matrix-assisted laser desorption/ionization mass spectrometry, a simple tip-based screening method for proteomics. J. Mass Spectrom. Soc. Jpn. 2006, 53, 187-193. Kodama, K.; Fukuzawa, S.; Nakayama, H.; Kigawa, T.; Sakamoto, K.; Yabuki, T.; Matsuda, N.; Shirouzu, M.; Takio, K.; Tachibana, K.; Yokoyama, S. Regioselective Carbon-Carbon Bond Formation in Proteins by Palladium-catalysis; New Protein Chemistry by Organometallic Chemistry. ChemBioChem 2006, 7, 134-139. Fukuzawa, S.; Asanuma, M.; Tachibana, K.; Hirota, H. On-probe sample preparation without washes for matrix assisted laser desorption ionization mass spectrometry based on a combination of electrostatic interactions and a molecular sieve effects. Anal. Chem. 2005, 77, 5750-5754. Sasaki, H.; Araki M.; Fukuzawa, S.; Tachibana, K. The Packing of Lipid Chains Changes the Character of Bacteriorhodopsin Reconstituted in a Model Membrane. Bioorg. Med. Chem. Lett. 2003, 13, 3583-3585. Sasaki, H.; Fukuzawa, S.; Kikuchi, J.; Yokoyama, S.; Hirota, H.; Tachibana, K. Cholesterol Doping Induced Enhanced Stability of Bicelles. Langmuir 2003, 19, 9841-9844. Kerns, R.; Dong S. D.; Fukuzawa, S.; Carbeck J.; Kohler, J.; Silver, L.; Kahne, D. The Role of Hydrophobic Substituents in the Biological Activity of Glycopeptide Antibiotics. J. Am. Chem. Soc. 2000, 122, 12608-12609. Ge, M.; Chen, Z.; Onishi, H. R.; Kohler, J.; Silver, L. L.; Kerns, R.; Fukuzawa, S.; Thompson, C.; Kahne, D. Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding D-Ala-D-Ala. Science 1999, 284, 507-511. Yamada, A.; Kitamura, H.; Yamaguchi, K.; Fukuzawa, S.; Kamijima, C.; Yazawa, K.; Kuramoto, M.; Wang, G-Y-S.; Fujitani, Y.; Uemura, D. Development of Chemical Substances Regulating Biofilm Formation. Bull. Chem. Soc. Jpn. 1997, 70, 3061-3069. Fukuzawa, S.; Matsunaga, S.; Fusetani, N. Isolation of 13 New Ritterazines from the Tunicate Ritterella tokioka and Chemical Transformation of Ritterazine B. J. Org. Chem. 1997, 62, 4484-4491. Fukuzawa, S.; Matsunaga, S.; Fusetani, N. Use of 15N-HMBC Techniques to Determine the Orientation of the Steroidal Units in Ritterazine A. Tetrahedron Lett. 1996, 37, 1447-1448. Fukuzawa, S.; Hayashi, Y.; Uemura, D.; Nagatsu, A.; Yamada, K.; Ijuin, Y. The Isolation and Structures of Five New Alkaloids, Norzoanthamine, Oxyzoanthamine, Norzoanthaminone, Cyclozoanthamine, and Epinorzoanthamine. Heterocycl. Commun. 1995, 1, 207-214. Fukuzawa, S.; Matsunaga, S.; Fusetani, N. Ten More Ritterazines, Cytotoxic Steroidal Alkaloids, from the Tunicate Ritterella tokioka. Tetrahedron 1995, 51, 6707-6716. Uemura, D.; Chou, T.; Haino, T.; Nagatsu, A.; Fukuzawa, S.; Zheng, S.; Chen, H. Pinnatoxin A; A Toxic Amphoteric Macrocycle from the Okinawan Bivalve Pinna muricata. J. Am. Chem. Soc. 1995, 117, 1155-1156. Fukuzawa, S.; Matsunaga, S.; Fusetani, N. Isolation and Structure Elucidation of Ritterazines B and C, Highly Cytotoxic Dimeric Steroidal Alkaloids, from the Tunicate Ritterella tokioka. J. Org. Chem. 1995, 60, 608-614. Fukuzawa, S.; Matsunaga, S.; Fusetani, N. Ritterazine A, a Highly Cytotoxic Dimeric Steroidal Alkaloid, from the Tunicate Ritterella tokioka. J. Org. Chem. 1994, 59, 6164-6166.