Brown, Lynda - University of Southampton

个人简介

Lynda graduated with BSc degree in Applied Chemistry from the University of Aston in 1996, spending a research placement year with GlaxoSmithKline. She then moved to the University of Southampton for doctoral research on novel fluorescent oligonucleotide probes under the supervision of Prof. Tom Brown. After obtaining her PhD in 2000, she worked as a research scientist for the Life Sciences company Eurogentec. In 2003 she returned to the University of Southampton as a postdoctoral research fellow developing new strategies for the production of imaging agents for use in positron emission tomography, and then working on the total synthesis of cis-sylvaticin. In 2009, she secured a Royal Society Dorothy Hodgkin Research Fellowship to pursue projects centred on enhancing the selectivity of organic reactions by synthesis within nanopores, developing new catalytic materials. In 2015 she moved to her current post of a Senior Research Fellow investigating the synthesis of multiply isotopically labelled molecules for imaging applications.

研究领域

My research involves the discovery of new catalytic materials based on mesoporous silica’s, where selectivity can be affected by spatial restrictions around the catalytic centre imposed by nanocavities. The criteria for success are identification of efficient and recyclable heterogeneous catalysts that give enhanced chemo-, regio- or enantioselectivities relative to their homogeneous counterparts. In turn, this project has led to the development of homogeneous catalysts for epoxidation of a range of olefins. Current research focuses on developing these catalysts further to favour enantioselective epoxidations. Another area of interest is the development of isotopically labelled molecular probes for application in medical imaging. I have collaborated in and led research projects spanning the areas of natural product synthesis, solid phase chemistries, heterogeneous catalytic materials and fluorescent DNA analysis. My current research involves the design and synthesis of isotopically labelled molecules to enable development of new methods in medical imaging. These molecules can be used to create hyper-polarised contrast agents that deliver enormously enhanced NMR signals (potentially many orders of magnitude over currently available technologies) with extended lifetimes allowing brighter images, higher resolution and access to remote organs not currently possible. Designing practical and efficient routes to these isotopically labelled molecules is challenging from a synthetic perspective due to constraints of limited availability of labelled starting materials and specific positioning of isotopes. Our ambition is to develop the next generation of contrast agents that incorporate water solubility and biocompatibility whilst retaining the extended lifetimes and enhanced signals.

近期论文

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Heterogenisation of ketone catalysts within mesoporous supports for asymmetric epoxidation - Brown, Lynda J., Brown, Richard C.D. and Raja, Robert Published:2013Publication:RSC AdvancesVolume:3, (3)Page Range:843-850doi:10.1039/c2ra21837b Long-lived nuclear singlet order in near-equivalent13C spin pairs - Pileio, Giuseppe, Hill-Cousins, Joseph T., Mitchell, Sam, Kuprov, Ilya, Brown, Lynda J., Brown, Richard C.D. and Levitt, Malcolm H. Published:2012Publication:Journal of the American Chemical SocietyVolume:134, (42)Page Range:17494-17497doi:10.1021/ja3089873 Total synthesis of cis-sylvaticin - Brown, L.J., Spurr, I.B., Kemp, S.C., Camp, N.P., Gibson, K.R. and Brown, R.C.D. Published:2008Publication:Organic LettersVolume:10, (12)Page Range:2489-2492doi:10.1021/ol800767e Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2-deoxy-d-glucose from resin-bound perfluoroalkylsulfonates - Brown, Lynda J., Ma, Nianchun, Bouvet, Denis R., Champion, Sue, Gibson, Alex M., Hu, Yulai, Jackson, Alex, Khan, Imtiaz, Millot, Nicolas, Topley, Amy C., Wadsworth, Harry, Wynn, Duncan and Brown, Richard C.D. Published:2009Publication:Organic & Biomolecular ChemistryVolume:7, (3)Page Range:564-575doi:10.1039/B816032ePMID:19156324