Lee, Seung Seo - University of Southampton

个人简介

Dr Seung Lee obtained his BSc and MSc in chemistry from Seoul National University in Seoul, Korea. He then worked in the pharmaceutical industry before starting his doctoral study in chemistry at University of British Columbia in Vancouver, Canada. He obtained his PhD under the supervision of Professor Stephen G Withers, studying the reaction mechanism of glycan processing enzymes. For his postdoctoral studies, he expanded his skillset to directed evolution techniques with Dr Florian Hollfelder in Department of Biochemistry at University of Cambridge and synthetic carbohydrate chemistry with Professor David R Bundle in the Department of Chemistry at University of Alberta. He then joined Professor Benjamin G Davis' group, working on various projects of chemical biology involving enzymes. In October 2012 he was appointed as a lecturer in Chemistry at University of Southampton.

研究领域

We have been employing a large variety of multidisciplinary techniques for our research. Some keywords for our expertise include: 1) chemical biology expertise (chemical probe synthesis, protein chemistry, labelling, phenotype analysis); 2) structural and functional analysis of proteins; 3) General organic chemistry & carbohydrate chemistry; 4) molecular biology; 5) enzyme research & assay development); 6) enzymatic synthesis; 7) biophysical techniques.

近期论文

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Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates - Wyszynski, Filip J., Lee, Seung Seo, Yabe, Tomoaki, Wang, Hua, Gomez-Escribano, Juan Pablo, Bibb, Mervyn J., Lee, Soo Jae, Davies, Gideon J. and Davis, Benjamin G. Published:2012Publication:Nature ChemistryVolume:4, (7)Page Range:539-546doi:10.1038/nchem.1351 Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides - Lee, Seung Seo, Greig, Ian R., Vocadlo, David J., McCarter, John D., Patrick, Brian O. and Withers, Stephen G. Published:2011Publication:Journal of the American Chemical SocietyVolume:133, (40)Page Range:15826-15829doi:10.1021/ja204829r Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase - Lee, Seung Seo, Hong, Sung You, Errey, James C., Izumi, Atsushi, Davies, Gideon J. and Davis, Benjamin G. Published:2011Publication:Nature Chemical BiologyVolume:7, (9)Page Range:631-638doi:10.1038/NCHEMBIO.628 Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis - Backus, Keriann M., Boshoff, Helena I., Barry, Conor S., Boutureira, Omar, Patel, Mitul K., D'Hooge, François, Lee, Seung Seo, Via, Laura E., Tahlan, Kapil, Barry, Clifton E. and Davis, Benjamin G. Published:2011Publication:Nature Chemical BiologyVolume:7, (4)Page Range:228-235doi:10.1038/NCHEMBIO.539PMID:21378984