Tavassoli, Ali - University of Southampton

个人简介

Ali Currently leads an interdisciplinary team of scientists whose efforts are focused on the development of novel chemical tools that enable new insight into the role of protein-protein interactions in cell biology, and as the starting point for new therapeutics. The main focus of the Tavassoli lab is the identification of cyclic peptide inhibitors of protein-protein interaction using a genetically encoded high-throughput screening platform. Our goal is the development of compounds capable of disrupting the association and assembly of protein complexes. The compounds uncovered in our lab serve as valuable tools that allow better understanding of the role of individual protein-protein interactions in cells. These compounds also form the starting point for the development of therapeutic compounds that target key protein-protein interactions in disease. Our research group is focused on training scientists at the chemistry-biology interface, and using these interdisciplinary skills to help understand the fundamentals of cell biology and to develop new therapeutic agents. Ali was Chair of the RSC's Chemical Biology and Bioorganic Group (2012-2015), and an elected member of the RSC's Chemistry and Biology Interface Division council (2012-2016). Ali has won a number of awards during his career, including the European Association for Chemical and Molecular Sciences' medal for European Young Chemist (in 2008).

近期论文

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Reprogramming the transcriptional response to hypoxia with a chromosomally encoded cyclic peptide HIF-1 inhibitor - Mistry, Ishna and Tavassoli, Ali Published:2016Publication:ACS Synthetic BiologyPage Range:1-20doi:10.1021/acssynbio.6b00219 Traceless production of cyclic peptide libraries in E. coli - Townend, Jaime and Tavassoli, Ali Published:2016Publication:ACS Chemical BiologyVolume:11Page Range:1624-1630doi:10.1021/acschembio.6b00095PMID:27027149 AMPK activation via modulation of de novo purine biosynthesis with an inhibitor of ATIC homodimerization - Asby, Daniel J., Cuda, Francesco, Beyaert, Maxime, Houghton, Franchesca D., Cagampang, Felino R. and Tavassoli, Ali Published:2015Publication:Chemistry & BiologyVolume:22, (7)Page Range:838-848doi:10.1016/j.chembiol.2015.06.008PMID:26144885 Transcription of click-linked DNA in human cells - Birts, Charles N., Sanzone, A. Pia, El-Sagheer, Afaf H., Blaydes, Jeremy P., Brown, Tom and Tavassoli, Ali Published:2014Publication:Angewandte Chemie International Edition in EnglishVolume:53, (9)Page Range:2362-2365doi:10.1002/anie.201308691PMID:24452865