Langley, John - University of Southampton

个人简介

John Langley has nearly 30 years’ experience in mass spectrometry and chromatography-mass spectrometry. He received a mass spectrometry PhD from the University of London where he started his working career. He is a Chartered Chemist (1999), a Fellow of the Royal Society of Chemistry (1999) and a Chartered Scientist (2004); he leads the Characterisation and Analytics section in Chemistry at Southampton, heads SCAS (Southampton Chemistry Analytical Solutions (http://www.southampton.ac.uk/scas/), is Chair of the Separation Science Group of the Royal Society of Chemistry (http://www.sep-sci.org.uk/) and Vice President of the International Mass Spectrometry Foundation 2009-14, Secretary of IMSF (http://www.imss.nl/). He was previously Chair, Vice-Chair, General Secretary and Meetings Secretary of the British Mass Spectrometry Society, a member of the Organisation Committee for the International Mass Spectrometry Conference for Edinburgh 2003 and Kyoto 2012, and BMSS Annual Conferences (1999-2010) John has been a member of the Organisation Committees for a number of National and International meetings and conferences including the International Mass Spectrometry Conference Edinburgh 2003, Kyoto 2012 and Geneva 2014,and BMSS Annual Conferences 1999, 2001, 2002, 2004, 2005 and 2007 and a number of RSC Separation Science Group meetings. He is currently a member of the BMSS Advisory Board, the Scientific Advisory Group for Microsaic, mass spectrometry consultant for LGC (Teddington) and has previously been an expert witness. He is a member of the EPSRC Peer Review College, a referee for Research Council and Charity research grant proposals, a member of the Editorial Board for Rapid Communications in Mass Spectrometry and a reviewer for all other leading mass spectrometry, chromatography and chemistry journals; was the European Member of IUPAC Task Group for Standard Definitions of Terms Relating to Mass Spectrometry. The Langley research group (http://www.southampton.ac.uk/~gjl/) are interested in the application of separation science and mass spectrometry as a routine tool for chemistry/chemical biology/oilfield chemistry as well as probing new areas for research using these tools. Specific interests are the application of hyphenated approaches (GC-MS, HPLC-MS & SFC-MS) to analysis of petrochemicals, oilfield, fuels and biofuels, research into analysis and detection of oligonucleotides and understanding fundamental MS/MS fragmentation processes and mechanism, the latter including the use of computational methods. John has been working with SFC-MS since 2004 and has an ongoing collaboration with Waters in this area, applying and developing Ultra Performance Convergence Chromatography-MS. His innovative and unique research has led to 90+ publications in over 30 leading scientific journals which reflect the multidisciplinary nature of the applications of this research, including Nature, Analytical Chemistry, Analyst, Chem. Sci., Journal of the American Chemical Society, Journal of American Society for Mass Spectrometry, Rapid Communications in Mass Spectrometry and Journal of Chromatography A. Since 2012 John has been invited to speak at ~30 national and international meetings, including 10 invited international and national presentations. The majority of the Langley group research activity has recently been aligned to the petrochemical industry, upstream, downstream areas and fuels (Energy and renewable fuels, BP and Innospec) though I also maintain innovative research in the active in oligonucleotide analysis (AstraZeneca) and lipid analysis with the Lipidomics Group in Southampton, Medicine. Applying new technologies and research approaches to a range of applications, e.g. impurity determination in therapeutic oligonucleotides. In the early nineties John worked with the Sussex group providing mass spectrometry expertise, analysis and data interpretation in the discovery of and a multitude of developments in the field of Fullerene chemistry.

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Self reporting RNA probes as an alternative to cleavable small molecule mass tags - Riley, Jo-Anne, Brown, Tom, Gale, Nittaya, Herniman, Julie and Langley, G. John Published:2012Publication:The AnalystVolume:137, (24)Page Range:5817-5822doi:10.1039/C2AN36086APMID:23096125 Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas - Gale, Philip A, Felix, Vitor, Pérez Tomás, Ricardo, Soto Cerrato, Vanessa, Haynes, Cally, Moore, Stephen, González, Jorge, Light, Mark E., Sutton, Jennifer, Marques, Igor, Herniman, Julie and Langley, John Published:2012Publication:Chemical ScienceVolume:4, (1)Page Range:103-117doi:10.1039/C2SC21112B A rapid methodology for the characterization of dialkyl tertiary amine-n-oxide metabolites using structurally dependent dissociation pathways and reconstructed ion current chromatograms - Holman, Stephen W., Wright, Patricia and Langley, G. John Published:2010Publication:Analytical ChemistryVolume:82, (6)Page Range:2347-2354doi:10.1021/ac902540b Effect of increasing concentration of ammonium acetate as an additive in supercritical fluid chromatography using CO2–methanol mobile phase - Cazenave-Gassiot, Amaury, Boughtflower, Robert, Caldwell, Jeffrey, Hitzel, Laure, Holyoak, Claire, Lane, Stephen, Oakley, Paul, Pullen, Frank, Richardson, Stefan and Langley, G. John Published:2009Publication:Journal of Chromatography AVolume:1216, (36)Page Range:6441-6450doi:10.1016/j.chroma.2009.07.022