Attard, George - University of Southampton

个人简介

George Attard graduated from the University of Warwick with a B.Sc. (Hons). Moving to the University of Southampton he joined the Chemical Physics group to study for a Ph.D. After a period as a Postdoctoral Research Fellow at the University College of Wales in Aberystwyth he returned to Southampton as a SERC Advanced Fellow. After two years as a Advanced Fellow took up a joint position as a Scientific Associate at Courtaulds Research, Coventry – where he headed up the Materials Physics Group within the corporate Strategic Research unit – and as Courtaulds Research Fellow in Southampton, where he continued with his fundamental research in materials science and in chemical biology. After three years in industry he moved to a full time Lectureship at the University, and was promoted to a Personal Chair. George set up and led the University’s strategic drive to develop distinctive research programmes at the interfaces between the physical sciences, the life sciences, engineering and medicine. He concurrently served as Associate Dean with responsibility for Research, Enterprise and Graduate Schools for the then Faculty of Engineering, Science and Mathematics. More recently he has played a leading role in developing the University’s Strategy for Interdisciplinary Research and served as the first Director of University Interdisciplinary Research. George is currently Associate Dean for Research for the Faculty of Natural and Environmental Sciences. He is also Programme Director of the innovative interdisciplinary Natural Sciences degree programme at Southampton.

研究领域

The primary focus of my research is on understanding the fundamental properties and behaviour of complex chemical systems. I have worked on self-organised/assembled systems throughout my career and have established a strong track record of discovery and innovation. Examples of this include: • the discovery that certain types of naturally-occuring glycosides, when formulated to produce self-assembled nanoparticles are potent modulators of immune responses . • the discovery that lyotropic liquid crystalline phases can be used as templates for the synthesis of nanostructured mesoporous oxides, semiconductors and metals , which led to the foundation of Nanotecture PLC, a University spin-out. • the discovery that dsDNA partitions spontaneously into the inverse hexagonal phases of lipids and is transcriptionally active; this was the basis for the EC-funded NEONUCLEI programme that I co-ordinated. • demonstrating that biomembrane stored curvature elastic energy plays a key role in regulating membrane-bound proteins and in controlling lipid biosynthetic networks . • I am the named inventor on eleven patent (PCT) applications My most recent research has been concerned with elucidating the way in which cells control their lipid biosynthetic networks. By using extensive experimental lipidomic data sets from both prokaryotic and eukaryotic cells, coupled with data driven modelling, we have identified the signature in vivo of network control by biomembrane stored curvature elastic energy. This is a significant result as it is the first report of a biochemical network being controlled by a non-chemical feedback signal. My current projects are concerned with how to tackle, understand and control complex chemical systems. For example, we have engaged in an extensive investigation of the ferroin-catalysed Belousov-Zhabotinsky reaction, and have mapped its complicated dynamic behaviour over a wide range of reaction conditions in both stirred and unstirred systems. We have used computational techniques to identify possible reaction networks that are consistent with these data. The aim of this work is to understand how the dynamics of the B reaction are affected by molecular crowding and by reduced dimensionality (e.g. through confinement in nanostructures) – both of which are features of biological systems. A separate project is concerned with setting up experimental systems that can produce artificial reaction networks that in terms of network metrics are indistinguishable from those observed in living systems. The aim of this work is to generate a collection of reaction systems that, though highly complex, are well defined and can be used as model systems to understand how to interact and control biological reaction networks.

近期论文

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An in vivo ratio control mechanism for phospholipid homeostasis: evidence from lipidomic studies - Dymond, M.K., Hague, C.V., Postle, A.D. and Attard, G.S. Published:2012Publication:Journal of The Royal Society InterfaceVolume:10, (80)Page Range:20120854doi:10.1098/rsif.2012.0854PMID:23256189 Linear dsDNA partitions spontaneously into the inverse hexagonal lyotropic liquid crystalline phases of phospholipids - Black, Camilla F., Wilson, Richard J., Nylander, Tommy, Dymond, Marcus K. and Attard, George S. Published:2010Publication:Journal of the American Chemical SocietyVolume:132, (28)Page Range:9728-9732doi:10.1021/ja101550cPMID:20575567 Integrative feedback and robustness in a lipid biosynthetic network - Beard, Jason, Attard, George S. and Cheetham, Matthew J. Published:2008Publication:Journal of the Royal Society InterfaceVolume:5, (22)Page Range:533-543doi:10.1098/rsif.2007.1155 DNA that is dispersed in the liquid crystalline phases of phospholipids is actively transcribed - Corsi, J., Dymond, M.K., Ces, O., Muck, J., Zink, D. and Attard, G.S. Published:2008Publication:Chemical CommunicationsVolume:2008, (20)Page Range:2307-2309doi:10.1039/b801199k Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress - Attard, G. S., Templer, R. H., Smith, W. S., Hunt, A. N. and Jackowski, S. Published:2000Publication:Proceedings of the National Academy of Sciences of the United States of AmericaVolume:97, (16)Page Range:9032-9036doi:10.1073/pnas.160260697