Paget, Timothy - Sunderland University - Department of Pharmacy, Health and Well-being

个人简介

Prof Tim Paget is a Professor of Medical Microbiology in the Faculty of Health Sciences and Wellbeing; he gained his PhD in 1987 on microbial/parasite biochemistry. After this he went on to complete a Wellcome funded postdoctoral post at Cardiff and during this time he also worked in the USA with Profs Lindmark and Jarroll both internationally renowned for their work on the biochemistry and physiology of Giardia. Since then he has worked as an academic in a number of institutions most recently before Sunderland he was Chair of Chemistry at Lehman College, City University of New York. During his career he has maintained his research interest in parasite physiology and his contribution to this area was highlighted when he was asked to organise the 65th meeting of the International Society for Protozoology held at the University of Kent at Canterbury, 2010. His research has also extended into the areas of microbial detection and pathogen control and this has lead to several industrial linked grants (with Smith and Nephew) and a large NEAT (DoH) grant.

研究领域

His current research covers a range of areas but his major focus is on an important but often overlooked parasite Giardia duodenalis. This parasite can be found worldwide but is endemic in many continents. It is also the most commonly isolated water borne pathogen in the UK. Giardia infects hundreds of millions of people every year and is a major cause of failure to thrive syndrome in children. He is involved in several projects looking at how Giardia regulates cell transformation during its life cycle and the factors that contribute to drug treatment failure. He is also interested in identifying new approaches for the control of microbial infections such as the development of new drugs for use in antimicrobial photodynamic therapy (the use of light and drugs activated by light to kill microorganisms) and developing novel methods for the detection of pathogens.

近期论文

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Anyanwu, Philip, Fulton, John, Paget, Timothy and Evans, Etta (2016) Socioeconomic Determinants of Antimalarial Drug Use Behaviours: A Systematic Review. Journal of Community and Public Health Nursing, 2 (2). ISSN 2471-9846 Siheri, W., Zhang, T., Unekwuojo Ebiloma, G., Biddau, M., Woods, N., Yassein Hussain, M., Clements, C., Fearnley, J., Edrada Ebel, R., Paget, Timothy, Muller, S., Carter, K.C., Ferro, V.A., De Koning, H.P. and Watson, D.G. (2016) Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya. PLOS ONE, 11 (5). ISSN 1932-6203 Alam, Muhammad Irfan, Paget, Timothy and Elkordy, Amal (2016) Characterisation of furazolidone-chitosan based spray dried microparticles regarding their drug release and mucin adsorptive properties. Powder Technology, 295. pp. 175-179. ISSN 0032-5910 Alam, Muhammad Irfan, Paget, Timothy and Elkordy, Amal (2016) Formulation and advantages of furazolidone in liposomal drug delivery systems. European Journal of Pharmaceutical Sciences, 84. pp. 139-145. Abulreesh, H.H., Paget, Timothy and Goulder, R. (2014) A pre-enrichment step is essential for detection of Campylobacter sp in turbid pond water. Tropical Biomedicine, 31 (2). pp. 320-326. Paget, Timothy, Haroune, Nicolas, Bagchi, S and Jarroll, E (2013) Metabolomics and Protozoan Parasites. Acta Parasitologica, 58 (2). pp. 127-131. ISSN 1230-2821 Koh, W, Geurden, T, Paget, Timothy, O'Handley, R, Steuart, R, Thompson, A and Buret, A G (2012) Giardia duodenalis assemblage-specific induction of apoptosis and tight junction disruption in human intestinal epithelial cells: Effects of mixed infections. The Journal of Parasitology. ISSN 0022-3395 Bagchi, S, Oniku, A E, Topping, K, Mamhoud, Z N and Paget, Timothy (2012) Programmed cell death in Giardia. Parasitology, 139 (7). pp. 894-903. ISSN 0031-1820