Carr-Wilkinson, Jane - Sunderland University - Department of Pharmacy, Health and Well-being

个人简介

Dr Jane Carr-Wilkinson is a Senior Lecturer in Physiological Sciences in the Department of Pharmacy, Health and Well-being. Her research interests are focussed on understanding the genes and signalling networks involved in cancer development and its progression. Jane's main focus is using stem cell models as a tool for modelling childhood cancer development and progression. Understanding normal neuronal development will provide useful insights into the molecular and cellular mechanisms underlying disease development and facilitate the discovery of targets for novel therapeutic intervention. She is also interested in DNA repair proteins and their role in neuroblastoma at different stages of therapy. She is interested, and actively involved, in public engagement. This includes speeches at the Cancer Research UK Race for Life and other CR-UK charity events throughout the region. She has participated in stem cell engagement events in collaboration with EuroStemCell including events at the Centre for life involving hands-on exhibits and activities to help people to understand stem cells and their unique properties.

研究领域

Jane’s main research interests involve the differentiation of human pluripotent stem cells down sympathetic neuronal lineages to generate physiological models of neuronal development. This can be used as a tool to investigate disease pathogenesis to: 1) Provide useful insights into the molecular and cellular networks underlying disease development 2) Facilitate the discovery of new biomarkers and targets for novel therapeutic intervention Jane’s other research interests are: The role of DNA repair proteins in neuroblastoma pathogenesis The application of Graphene as a biosensor and a novel method of drug delivery in cancer The role of tumour suppressor gene pathway abnormalities such as the p53/MDM2/p14ARF network in relapse and in the development of chemoresistance in childhood cancer

近期论文

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Forgham, Helen, Johnson, Darren, Carter, Noel, Veuger, Stephany and Carr-Wilkinson, Jane (2015) Stem Cell Markers in Neuroblastoma—An Emerging Role for LGR5. Frontiers in Cell and Developmental Biology, 3 (77). ISSN 2296-634X Carr-Wilkinson, Jane, Prathalingam, N, Pal, D, Moad, M, Lee, N, Sundaresh, A, Lako, M, Murdoch, A P, Herbert, M and Deborah, A (2013) Differentiation of human pluripotent stem cells to sympathetic neurons: A model for understanding neuroblastoma pathogenesis. Stem Cells and Translational Medicine. ISSN 2157-6564 (Submitted) Moad, M, Pal, D, Hepburn, A C, Williamson, S C, Wilson, L, Lako, M, Armstrong, L, Hayward, S W, Franco, O E, Cates, J M, Fordham, S E, Przyborski, S, Carr-Wilkinson, Jane and Robson, C N (2013) A Novel Model of Urinary Tract Differentiation, Tissue Regeneration, and Disease: Reprogramming Human Prostate and Bladder Cells into Induced Pluripotent Stem Cells. European Urology. ISSN 0302-2838 (In Press) Carr-Wilkinson, Jane, Wylie, Luke, Gray, Juliet and Anderson, John (2012) Neuroblastoma progress - future treatments for high risk neuroblastoma. Paediatric Blood and Cancer, 59 (3). pp. 594-596. Carr-Wilkinson, Jane, Griffiths, R, Elston, R, Goranov, B, Redfern, C P F, Gamble, L D, Lunec, J and Tweddle, D A (2011) Outcome of the p53-mediated DNA damage response in neuroblastoma is determined by morphological subtype and MYCN expression. Cell Cycle, 10 (21). pp. 3778-3787. ISSN 1538-4101 Carr-Wilkinson, Jane, O'Toole, K, Wood, K M, Challen, C C, Baker, A G, Board, J R, Evans, L, Cole, M, Cheung, N V, Boos, J, Kohler, G, Leuschner, I, Pearson, A D J, Lunec, J and Tweddle, D A (2010) High frequency of p53/MDM2/p14ARF pathway abnormalities in relapsed neuroblastoma. Clinical Cancer Research, 16 (4). pp. 1108-1118. ISSN 1078-0432