Darby, Steven - Sunderland University - Department of Pharmacy, Health and Well-being

个人简介

Dr Steve Darby is a Senior Lecturer in Biomedical Sciences in the Department of Pharmacy, Health and Well-being. His research interests are focussed on understanding the genes and intracellular signalling networks involved in cancer development and progression.

研究领域

Novel drug target identification/validation Aberrant growth factor signalling in cancer Molecular Pathology of Cancer Post translational modification of proteins Identification of novel binding proteins in molecular complexes

近期论文

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Rodriguez-Teja, M., Gronau, J. H., Minamidate, A., Darby, Steven, Gaughan, L., Robson, C., Mauri, F., Waxman, J. and Sturge, J. (2015) Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147. Molecular Cancer Research, 13 (3). pp. 538-547. ISSN 1541-7786 Rodriguez-Teja, m, Gronau, JH, Breit, C, Zhang, YZ, Minamidate, A, Caley, MP, McCarthy, A, Cox, TR, Erler, JT, Gaughan, L, Darby, Steven, Robson, CN, Mauri, F, Waxman, J and Sturge, J (2015) AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival. Journal of Pathology, 235 (4). pp. 581-592. ISSN 1096-9896 Burska, U. L., Harle, V. J., Coffey, K., Darby, Steven, Ramsey, H., O'Neill, D., Logan, I. R., Gaughan, L. and Robson, C. N. (2013) Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor. Journal of Biological Chemistry, 288 (45). pp. 32641-32650. ISSN 0021-9258 Coffey, K., Rogerson, L., Ryan-Munden, C., Alkharaif, D., Stockley, J., Heer, R., Sahadevan, K., O'Neill, D., Jones, D., Darby, Steven, Staller, P., Mantilla, A., Gaughan, L. and Robson, C. N. (2013) The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover. Nucleic Acids Research, 41 (8). pp. 4433-4446. ISSN 0305-1048 Valencia, Tania, Joseph, Ajay, Kachroo, Naveen, Darby, Steven, Meakin, Susan and Gnanapragasam, Vincent J (2011) Role and expression of FRS2 and FRS3 in prostate cancer. BMC Cancer, 11 (1). ISSN 1471-2407 Dafou, D, Grun, B, Sinclair, J, Lawrenson, K, Benjamin, EC, Hogdall, E, Kruger-Kjaer, S, Christensen, L, Sowter, HM, Al-Attar, A, Edmondson, R, Darby, Steven, Berchuck, A, Laird, PW, Pearce, CL, Ramus, SJ, Jacobs, IJ and Gayther, SA (2010) Microcell-Mediated Chromosome Transfer Identifies EPB41L3 as a Functional Suppressor of Epithelial Ovarian Cancers. Neoplasia, 12 (7). pp. 579-589. ISSN 1522-8002