研究领域

Organic Chemistry and Chemical Biology

Our research is directed towards the synthesis of small molecule entities with biological activity. In particular we are interested in the preparation of peptidomimetics containing unnatural peptide bonds such as sulfonamides since this group has recently been shown to be a transition state mimetic of peptide hydrolysis and potent irreversible inhibitors of cysteine proteases. The course of this research has led us to a number of other areas including total synthesis of natural products and novel synthetic methodology.

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Gray, V. J., Slater, B., Wilden, J. D. (2012). Transition-Metal-Free Synthesis of Aryl-Substituted tert-Butyl Ynol Ethers through Addition/Elimination Substitution at an sp Centre. CHEMISTRY-A EUROPEAN JOURNAL 18(49), 15582-15585 doi:10.1002/chem.201203015. Author URL Gray, V. J., Wilden, J. D. (2012). A selective, tin-free radical mediated synthesis of indoles based on a sulfonate template. TETRAHEDRON LETTERS 53(1), 41-44 doi:10.1016/j.tetlet.2011.10.093. Author URL Pritchard, D. R., Wilden, J. D. (2010). An enantioselective synthesis of the bicyclic core of the marine natural product awajanomycin. TETRAHEDRON LETT 51(14), 1819-1821 doi:10.1016/j.tetlet.2010.01.123. Wilden, J. D. (2010). The sulfonamide motif as a synthetic tool. J CHEM RES (10), 541-548 doi:10.3184/030823410X12857514635822. Aliev, A. E., Sinclair, A. J., Zhou, S., Wilden, J. D., Caddick, S., Kullmann, D. M., Rusakov, D. A. (2009). Density functional and spectroscopic studies of nitrogen inversion in substituted dizocilpines. Journal of Physical Organic Chemistry 22(6), 607-612 doi:10.1002/poc.1490. Author URL Wilden, J. D., Mavri-Damelin, D., Mani, A. -. R., Selden, C., Hodgson, H. J. F., Damelin, L. H. (2009). The Use of 3-Aminophthalimide as a Pro-Chemiluminescent Label in Chemiluminescence and Fluorescence-Based Cellular Assays. Bioconjugate Chemistry 20(2), 266-273, 10.1021/bc800361r US doi:10.1021/bc800361r. Publisher URL Chudasama, V., Wilden, J. D. (2008). A versatile synthesis of 2,4-substituted oxazoles. CHEM COMMUN (32), 3768-3770 doi:10.1039/b805430d. Edetanlen-Elliot, O., Fitzmaurice, R. J., Wilden, J. D., Caddick, S. (2007). Tributyltin hydride and 1-ethylpiperidine hypophosphite mediated intermolecular radical additions to 2,4,6-trichlorophenyl vinyl sulfonate. Tetrahedron Letters 48(50), 8926-8929 doi:10.1016/j.tetlet.2007.10.030. Author URL Wilden, J. D., Geldeard, L., Lee, C. C., Judd, D. B., Caddick, S. (2007). Trichlorophenol (TCP) sulfonate esters: A selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides. Chemical Communications (10), 1074-1076 doi:10.1039/b614604j. Lewis, A. K., Mok, B. J., Tocher, D. A., Wilden, J. D., Caddick, S. (2006). New synthesis of beta-sultams from pentafluorophenyl sulfonates. Organic Letters 8(24), 5513-5515 doi:10.1021/ol062164b. Wilden, J. (2006). Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates. Chemical Communications (44), 5563-5565 Caddick, S., Wilden, J. D., Judd, D. B. (2005). Observations on the reactivity of pentafluorophenyl sulfonate esters. Chemical Communications , 2727-2728 doi:10.1039/b501212k. Vallance, P., Bush, H. D., Mok, B. J., Hurtado-Guerrero, R., Gill, H., Rossiter, S., Wilden, J. D., Caddick, S. (2005). Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates. Chemical Communications (44), 5563-5565 doi:10.1039/b510709a. Vallance, P., Bush, H., D, M., B J, H. -. G., R, G., H, R., S, W., J, C., S, (2005). Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP). Chemical Communications (44), 5563-5565 doi:10.1039/b510709a. Wilden, J. D., Judd, D. B., Caddick, S. (2005). Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media. Tetrahedron Letters 46, 7637-7640 doi:10.1016/j.tetlet.2005.08.088. Caddick, S., Hamza, D., Judd, D. B., Reich, M. T., Wadman, S. N., Wilden, J. D. (2004). A novel route to functionalized PFP esters via rapid intermolecular radical addition to PFP acrylate mediated by ethylpiperidinium hypophosphite (EPHP). Tetrahedron Letters (45), 2363-2366 doi:10.1016/j.tetlet.2004.01.082. Caddick, S., Wilden, J. D., Judd, D. B. (2004). Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids. Journal of the American Chemical Society 126, 1024-1025 doi:10.1021/ja0397658. Judd, D. B., Stephen, C., Wilden, J. D. (2004). Synthesis of sulfonamides from activated sulfonate esters and sulfonic acids. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. ( Vol. 227 pp.U130-U130). AMER CHEMICAL SOC. Wilden, J. (2004). Synthesis of functionalised sulfonamides via microwave assisted displacement of PFP-sulfonates with amines. QSAR and Combinatorial Science 23(10), 902-905 Caddick, S., Wilden, J. D., Bush, H. D., Wadman, S. N., Judd, D. B. (2002). A new route to sulfonamides via intermolecular radical addition to pentafluorophenyl vinylsulfonate and subsequent aminolysis. ORGANIC LETTERS 4(15), 2549-2551 doi:10.1021/ol026181m. Harrowven, D. C., Wilden, J. D., Tyte, M. J., Hursthouse, M. B., Coles, S. J. (2001). A new approach to the pseudopterosins using an arene alkylation with a gamma-methylene-gamma-butyrolactone. TETRAHEDRON LETT 42(6), 1193-1195