Veuger, Stephany - Sunderland University - Department of Pharmacy, Health and Well-being

个人简介

Dr Stephany Veuger is a Senior Lecturer in Clinical Biochemistry in the Department of Pharmacy, Health and Well-being. A major focus of her research has been to evaluate DNA repair inhibitors as potential drugs to be used in combination with current therapies or as stand-alone therapies in cancer treatment. She has supported anticancer drug discovery projects by (1) evaluating drugs to exploit underlying molecular defects in a range of human cancers (2) investigating interactive effects of proteins involved in the sensing and responding to DNA damage (3) developing and validating pharmacodynamic biomarkers for agents progressing to clinical trials. She has played a key role within the drug development group at the Northern Cancer Centre where her work evaluating agents progressing to clinical trials and in developing biomarkers contributed towards the successful introduction of PARP inhibitors into patients.

研究领域

Stephany's current research is focussed on the mechanisms of DNA repair following ionising radiation/chemotherapeutic drugs and the role of NFkappa B in mediating resistance. Much of this is mechanistic in nature and relates an understanding of the contribution of activated NFkappa B to cellular responses to DNA damage with disease resistance to therapy. This is important as by defining resistance mechanisms to IR and clinically important DNA damaging agents, it has important implications for the way in which cancer therapies are used and how future regimens may be developed (disease to medicine use). She has an interest in both solid tumours and haematological malignancies (AML, CLL). Translational studies - so called- ‘bench to bedside’ are the focus of some of her research in chronic lymphoblastic leukaemia (CLL) and the application of DNA-PK or ATM inhibitors. This work is currently under review.

近期论文

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Forgham, Helen, Johnson, Darren, Carter, Noel, Veuger, Stephany and Carr-Wilkinson, Jane (2015) Stem Cell Markers in Neuroblastoma—An Emerging Role for LGR5. Frontiers in Cell and Developmental Biology, 3 (77). ISSN 2296-634X Hunter, J E, Willmore, E, Irving, J A E, Hosomsky, Z, Durkacz, B W and Veuger, Stephany (2012) NF kappaB mediates radiosensitisation by the PARP inhibitor AG-014699. Oncogene, 31 (2). pp. 251-254. ISSN 0950-9232 Mulligan, E, Hunter, J, Baird, A, Elliot, S, Summerfield, G, Parker, C, Veuger, Stephany, Pepper, C, Durkacz, B and Willmore, E (2011) Expression and function of the NFkB subunits in chronic lymphocytic leukaemia : A role for DNA dependent protein kinase in regulating DNA damage activated p65 and p50 subunit activation. Clinical Lymphoma Myeloma and Leukemia, 11 (S2). S167-S168. ISSN 2152-2650 Veuger, Stephany and Durkacz, B W (2011) Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radiosensitisation in the absence of NF kappa B activation. DNA Repair - Responses to DNA damage and other aspects of genomic stability, 10 (2). pp. 235-244. ISSN 1568-7864 Veuger, Stephany, Hunter, J E and Durkacz, B W (2009) Ionizing radiation-induced NF-kappa B activation requires PARP-1 function to confer radioresistance. Oncogene, 28 (6). pp. 832-842. ISSN 0950-9232 Hunter, J E, Hostomsky, Z, Durkacz, B W and Veuger, Stephany (2009) Radio-sensitization by a potent and specific PARP-1 inhibitor is mediated by NF-κB. Proceedings of the American Association for Cancer Research, 1285. ISSN 0569-2261