Ahmed, Shafiq - Sunderland University - Department of Pharmacy, Health and Well-being

个人简介

Dr Shafiq Ahmed joined the Department of Pharmacy, Health and Well-being as a Senior Lecturer in Biochemistry in February 2016. Shafiq graduated from Queen Mary (University of London) in 2001 with a BSc (Hons) in Biochemistry and completed his PhD in 2005 from the Northern Institute for Cancer Research, University of Newcastle where he developed small molecule inhibitors targeting protein-protein interaction for the treatment of cancers. He then undertook postdoctoral research at the University York investigating basal signalling pathways governing cancer cell survival to identify targets for drug development and contributed to the undergraduate teaching programme. Shafiq then moved to CRUK Beaton Institute, Glasgow in 2011 as a postdoctoral researcher and then relocated to the Institute of Cancer Sciences, University of Glasgow. His research focused on Glioblastomas; an incurable brain tumour through examination of a subpopulation of treatment resistant Glioblastoma stem-like cells (GSCs) using state-of-the-art radiation, flow cytometry, imaging and in vivo models.

研究领域

His main research focus is in the development and identification of novel therapeutics for the treatment of Glioblastomas (GBMs). This is the most common form of primary brain tumour in adults with inevitable tumour recurrence despite optimal multimodality treatment consisting of surgery, chemotherapy and radiotherapy. This is thought to be driven by a population of GBM stem-like cells (GSCs) which are resistant to the conventional therapies and give rise to new tumours. Shafiq’s research has identified optimal strategies to target GSC population and revealed distinct metabolic alterations in GSCs circuitry. His current research focuses on metabolomics, DNA damage signalling, high throughput siRNA and drug library screening in GSCs with the aim to identify and develop novel therapeutics to improve outcomes for patients with glioblastoma.

近期论文

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Kaur, A., Denisova, O., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, Shafiq, Raheem, O., Haapasalo, H. K., Eriksson, J., Chalmers, A. J., Laakkonen, P. M. and Westermarck, J. (2016) PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells. Cancer Research. ISSN 0008-5472 Tardito, S, Oudin, A, Ahmed, Shafiq, Fack, F, Keunen, O, Zheng, L, Miletic, H, Sakariassen, P, Weinstock, A, Wagner, A, Lindsay, S, Hock, A, Barnett, S, Ruppin, E, Morkve, S, Lund-Johansen, M, Chalmers, A, Bjerkvig, R, Niclou, S and Gottlieb, E (2015) Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restriced glioblastoma. Nature Cell Biology, 17 (12). pp. 1556-1568. Ahmed, Shafiq, Carruthers, R, Gilmour, L, Yildirim, S, Watts, C and Chalmers, A (2015) Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells. Cancer Research, 75 (20). pp. 4416-4428. Ichim, G, Lopez, J, Ahmed, Shafiq, Muthalagu, N, Giampazolias, E, Delgado, E, Parsons, MJ, Kooij, BVD, Bouchier-Hayes, L, Chalmers, A, Borst, J, Oberst, A, Rehm, M, Murphy, DJ and Tait, SWG (2015) Limited mitochondrial permeabilisation causes DNA-damage and genomic instability in the absence of cell death. Molecular Cell, 57 (5). pp. 860-872. Carruthers, R, Ahmed, Shafiq, Gomez-Roman, N, Amoah-Buahin, E, Watts, C and Chalmers, A (2015) Abrogation of radioresistance in in glioblastoma stem-like cells by inhibition of ATM kinase. Molecular Oncology, 9 (1). pp. 192-203. Blackburn, TJ, Ahmed, Shafiq, Coxon, CR, Liu, J, Lu, X, Golding, BT, Griffin, RJ, Hutton, C, Newell, DR, Ojo, S, Watson, AF, Zaytzev, A, Zhao, Y, Lunec, J and Hardcastle, IR (2013) Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions. Med. Chem. Commun., 4 (9). pp. 1297-1304.