Carlile, Mark - Sunderland University - Department of Pharmacy, Health and Well-being

个人简介

Dr Mark Carlile is a Senior Lecturer in Biopharmaceutical Sciences in the Department of Pharmacy, Health and Well-being. His research interests are focussed on non-coding RNA molecules and protein therapeutics.

研究领域

Non-coding RNA molecules Noncoding RNAs (ncRNAs) are transcripts that generally have no protein-coding capacity. However, many ncRNAs have been found to play a major role in human physiology. The deregulation of RNA metabolism has been implicated in many human diseases, but the exact roles of ncRNAs are only beginning to be elucidated. An increasing number of research groups are investigating the biology of ncRNAs and their use as a novel source of biomarkers in many pathological states. My work here at Sunderland will focus on the roles of ncRNAs in developmental biology and tissue regeneration. Protein Therapeutics Recombinant protein therapeutics have changed the face of modern medicine in the past decade, and they continue to provide innovative and effective therapies for numerous pathologies. Today, they are used in the treatment of a variety of human diseases, ranging from cancers to infertility. My work here at Sunderland will focus on the identification, design and formulation of recombinant protein therapeutics; specifically monoclonal antibodies (mAb) and mAb-conjugates.

近期论文

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Abu Abed, Omar S., Elkordy, Amal, Chaw, Cheng Shu, Williams, Lee and Carlile, Mark (2016) Development and Characterisation of Polymeric Nanacapsules Containing Macromolecule. Molecular Therapy, 24 (Supp 1). S237-S238. ISSN 1525-0016 Werner, Andreas, Cockell, Simon, Falconer, Jane, Carlile, Mark, Alnumeir, Sammer and Robinson, John (2014) Contribution of natural antisense transcription to an endogenous siRNA signature in human cells. BMC Genomics., 15 (19). pp. 1471-2164. ISSN 1471-2164 Carlile, Mark, Swan, D, Jackson, K, Preston-Fayers, K, Flicek, P and Werner, A (2009) Strand selective generation of endo-siRNAs from the Na/phosphate transporter gene Slc34a1 in murine tissues. Nucleic Acids Research, 37 (7). pp. 2274-2282. ISSN 0305-1048 Werner, A, Carlile, Mark and Swan, D (2009) What do natural antisense transcripts regulate? RNA Biology, 6 (1). pp. 43-48. ISSN 1547-6286 Carlile, Mark, Nalbant, P, Preston-Fayers, K, McHaffie, G S and Werner, A (2008) Processing of naturally occurring sense/antisense transcripts of the vertebrate Slc34a gene into short RNAs. Physiological Genomics, 34 (1). pp. 95-100. ISSN 1094-8341 Werner, A, Schmutzler, G, Carlile, Mark, Miles, C G and Peters, H (2007) Expression profiling of antisense transcripts on DNA arrays. Physiological Genomics, 28 (3). pp. 294-300. ISSN 1094-8341