个人简介
Dr Graeme O’Boyle is a Senior Lecturer in Immunology in the Department of Pharmacy, Health and Well-being. His research area is chemokines, which are a family of proteins that control the directional movement of cells throughout the body. They have a key role in the functioning of the immune system where they direct white blood cells to migrate from the blood stream into inflamed tissues. Chemokines are also involved in the metastatic spread of cancers from their initial site to other organs. His work has focused on endogenous mechanisms that regulate chemokine biology with a view to understanding how they might be targeted for therapeutic intervention. His work has been translated to a number of inflammatory diseases such as rheumatoid arthritis, transplant rejection (both bone marrow and solid organ), and inflammatory bowel disease. He also works on the pathological migration of breast and skin cancers to the lung and liver.
研究领域
Current research projects and collaborations with leading researchers from around the UK and overseas:
Using small molecule chemokine receptor agonists to define a new type of anti-inflammatory therapy in graft-versus-host-disease in collaboration with Professor Simi Ali and Professor John Kirby (Newcastle University)
Exploring the role of the atypical chemokine receptor D6 in transplant rejection with Professor Gerry Graham (University of Glasgow)
Studying how post-translational modifications alter the function and our ability to detect chemokines (impacting on biomarker development) with Professor Antonella Viola (Istituto Clinico Humanitas, Milan)
Examining the metastatic spread of melanoma to the liver with Professor Ruth Plummer and Dr Penny Lovat (Newcastle University)
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Barker, Catriona E., Ali, Simi, O'Boyle, Graeme and Kirby, John A. (2014) Transplantation and Inflammation: implications for the modification of chemokine function. Immunology, 143 (138-14). ISSN 1365-2567
京公网安备 11010802027423号