个人简介

Alethea Tabor is Professor of Chemical Biology, and has been at UCL since 1995 (Senior Lecturer 2001 - 2004, Reader 2004 – 2012). Her research is interdisciplinary and spans the interfaces between organic chemistry, biochemistry and in vivo imaging. He group has a particular focus on the design and synthesis of novel and complex peptides to investigate biological problems and as building blocks for the development of self-assembling, multifunctional nanoparticles: often this involves the development of new synthetic methodology.

研究领域

Organic Chemistry and Chemical Biology

Chemical Biology Synthesis and mode of action of antimicrobial peptides, particularly the lantibiotics Conformationally constrained peptides Targeted liposome-based nanoparticles for simultaneous imaging and delivery of cancer therapeutics

近期论文

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Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., . . . Ng, T. (2017). Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor. Oncogene. doi:10.1038/onc.2016.522 Kudsiova, L., Welser, K., Campbell, F., Mohammadi, A., Dawson, N., Cui, L., . . . Tabor, A. B. (2016). Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting. MOLECULAR BIOSYSTEMS, 12 (3), 934-951. doi:10.1039/c5mb00754b Tummeltshammer, C., Portnoi, M., Mitchell, S. A., Lee, A. -. T., Kenyon, A. J., Tabor, A. B., & Papakonstantinou, I. (2016). On the Ability of Förster Resonance Energy Transfer to Enhance Luminescent Solar Concentrator Efficiency. Nano Energy. doi:10.1016/j.nanoen.2016.11.058 Murray, P. M., Bellany, F., Benhamou, L., Bučar, D. K., Tabor, A. B., & Sheppard, T. D. (2015). The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry. Organic and Biomolecular Chemistry, 14 (8), 2373-2384. doi:10.1039/c5ob01892g Sayer, J. R., Walldén, K., Pesnot, T., Campbell, F., Gane, P. J., Simone, M., . . . Tabor, A. B. (2014). 2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion. Bioorganic and Medicinal Chemistry, 22 (22), 6459-6470. doi:10.1016/j.bmc.2014.09.036 Wright, Z. V. F., Tabor, A. B., Hall, A., Arstad, E., & Koltzenburg, M. (2014). Probing pain receptors with cysteine knot peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248. AMER CHEMICAL SOC. Tabor, A. B. (2014). Recent advances in synthetic analogues of lantibiotics: What can we learn from these?. Bioorg Chem, 55, 39-50. doi:10.1016/j.bioorg.2014.04.004 Welser, K., Campbell, F., Kudsiova, L., Mohammadi, A., Dawson, N., Hart, S. L., . . . Tabor, A. B. (2013). Gene delivery using ternary lipopolyplexes incorporating branched cationic peptides: the role of Peptide sequence and branching. Mol Pharm, 10 (1), 127-141. doi:10.1021/mp300187t Mitchell, N., Kalber, T. L., Cooper, M. S., Sunassee, K., Chalker, S. L., Shaw, K. P., . . . Tabor, A. B. (2013). Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging. Biomaterials, 34 (4), 1179-1192. doi:10.1016/j.biomaterials.2012.09.070 Kenny, G. D., Tagalakis, A. D., Hart, S. L., Lythgoe, M. F., Bienemann, A. S., Gill, S. S., . . . Hailes, H. C. (2013). Multifunctional receptor-targeted nanocomplexes for the delivery of therapeutic nucleic acids to the Brain. Biomaterials. doi:10.1016/j.biomaterials.2013.07.081 Barua, N. U., Miners, J. S., Bienemann, A. S., Wyatt, M. J., Welser, K., Tabor, A. B., . . . Gill, S. S. (2012). Convection-enhanced delivery of neprilysin: a novel amyloid-β-degrading therapeutic strategy. J Alzheimers Dis, 32 (1), 43-56. doi:10.3233/JAD-2012-120658 Kenny, G. D., Villegas-Llerena, C., Tagalakis, A. D., Campbell, F., Welser, K., Botta, M., . . . Hart, S. L. (2012). Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours. Biomaterials, 33 (29), 7241-7250. doi:10.1016/j.biomaterials.2012.06.042 Tulone, C., Sponaas, A. M., Raiber, E. A., Tabor, A. B., Langhorne, J., & Chain, B. M. (2011). Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1. PLoS One, 6 (10), e24886-?. doi:10.1371/journal.pone.0024886 Tagalakis, A. D., Grosse, S. M., Meng, Q. H., Mustapa, M. F., Kwok, A., Salehi, S. E., . . . Hart, S. L. (2011). Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration. Biomaterials, 32 (5), 1370-1376. doi:10.1016/j.biomaterials.2010.10.037 Kudsiova, L., Ho, J., Fridrich, B., Harvey, R., Keppler, M., Ng, T., . . . Lawrence, M. J. (2011). Lipid chain geometry of C14 glycerol-based lipids: effect on lipoplex structure and transfection. Mol Biosyst, 7 (2), 422-436. doi:10.1039/c0mb00149j Kudsiova, L., Fridrich, B., Ho, J., Mustapa, M. F., Campbell, F., Welser, K., . . . Lawrence, M. J. (2011). Lipopolyplex ternary delivery systems incorporating C14 glycerol-based lipids. Mol Pharm, 8 (5), 1831-1847. doi:10.1021/mp2001796 Mitchell, N., Kalber, T., Cooper, M., Cheung, A., Fruhwirth, G., Blower, P., . . . Tabor, A. B. (2011). Multimodal imaging of drug delivery using liposomes functionalised with MRI, PET and SPECT contrast agents to target sites of pathological interest. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 242. Manunta, M. D., McAnulty, R. J., Tagalakis, A. D., Bottoms, S. E., Campbell, F., Hailes, H. C., . . . Hart, S. L. (2011). Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium. PLoS One, 6 (10), e26768-?. doi:10.1371/journal.pone.0026768 Campbell, F., Welser, K., Mohammadi, A., Kudsiova, L., Lawrence, M. J., Tabor, A. B., & Hailes, H. C. (2011). Non-viral, coated nanoparticles as vectors for gene therapy. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 242. Tabor, A., Mothia, B., Wadman, S., & Appleyard, A. (2011). Solid-Phase Synthesis of Peptides Containing Overlapping Lanthionine Bridges: An Analogue of Nisin Rings D and E. BIOPOLYMERS, 96 (4), 446. WILEY-BLACKWELL. Mothia, B., Appleyard, A. N., Wadman, S., & Tabor, A. B. (2011). Synthesis of peptides containing overlapping lanthionine bridges on the solid phase: an analogue of rings D and E of the lantibiotic nisin. Org Lett, 13 (16), 4216-4219. doi:10.1021/ol201548m Tabor, A. B. (2011). The challenge of the lantibiotics: synthetic approaches to thioether-bridged peptides. Org Biomol Chem, 9 (22), 7606-7628. doi:10.1039/c1ob05946g Welser, K., Campbell, F., Mohammadi, A., Kudsiova, L., Dawson, N. L., Lawrence, M. J., . . . Tabor, A. B. (2011). Tuning a gene delivery vector: the role of peptide sequence and peptide branching in delivering of DNA and siRNA to the cytoplasm. BIOPOLYMERS, 96 (4), 516. WILEY-BLACKWELL. Koerner, C., Raiber, E. -. A., Keegan, S. E. M., Nicolau, D. C., Sheppard, T. D., & Tabor, A. B. (2010). An expedient synthesis of orthogonally protected lysinoalanine from Aloc-protected Garner's aldehyde. TETRAHEDRON LETTERS, 51 (49), 6381-6383. doi:10.1016/j.tetlet.2010.09.119 Chaudhry, B. R., Wilton-Ely, J. D. E. T., Tabor, A. B., & Caruana, D. J. (2010). Effect of peptide orientation on electron transfer. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 12 (34), 9996-9998. doi:10.1039/c0cp00226g